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AB171708

Recombinant Human OXSM protein (His tag N-Terminus)

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Recombinant Human OXSM protein (His tag N-Terminus) is a Human Full Length protein, in the 28 to 459 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Beta-ketoacyl-ACP synthase, OXSM

1 Images
SDS-PAGE - Recombinant Human OXSM protein (His tag N-Terminus) (AB171708)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human OXSM protein (His tag N-Terminus) (AB171708)

15% SDS-PAGE analysis of ab171708 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9NWU1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSKRKFFGTVPISRLHRRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRGSDEGQFNEQNFVSKSDIKSMSSPTIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALSTNSDPKLACRPFHPKRDGFVMGEGAAVLVLEEYEHAVQRRARIYAEVLGYGLSGDAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEKRFIGLTNSFGFGGTNATLCIAGL","proteinLength":"Full Length","predictedMolecularWeight":"48.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":459,"aminoAcidStart":28,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NWU1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OXSM also known as 3-oxoacyl-[acyl-carrier-protein] synthase mitochondrial is an important enzyme in the mitochondrial fatty acid synthesis pathway. It participates in the elongation of fatty acids by catalyzing a ketoacyl synthesis reaction. This protein has a molecular mass of approximately 50 kDa. OXSM is mainly expressed in tissues with high metabolic activity such as liver and muscle tissues where it supports the dynamic balance of fatty acid synthesis.
Biological function summary

OXSM plays a part in mitochondrial lipid homeostasis by facilitating the synthesis of longer chain fatty acids. It operates as part of a multiprotein complex that ensures proper substrate channeling and processing. This function is critical for the maintenance and functioning of cellular membranes providing the necessary lipid components. Additionally OXSM contributes to energy production by generating fatty acids that can be converted into acetyl-CoA units within the mitochondria.

Pathways

Several metabolic pathways involve OXSM including the mitochondrial fatty acid synthesis and the broader lipid metabolism pathway. In the mitochondrial fatty acid synthesis pathway OXSM interacts with proteins like Acyl-CoA synthetase family member 1 (ACSF1) to facilitate the progression of fatty acid synthesis. These pathways collectively contribute to energy homeostasis and cellular membrane composition reflecting the interconnectivity between various metabolic functions.

Researchers associate OXSM with rare mitochondrial disorders linked to lipid metabolism. For instance mutations or dysfunctions in OXSM can result in compromised mitochondrial function potentially contributing to neuromuscular disorders. It also connects to carnitine palmitoyltransferase 1A (CPT1A) another key enzyme in fatty acid metabolism which highlights the interconnected nature of mitochondrial metabolic disorders. Understanding OXSM's role in these conditions can lead to better insights for therapeutic strategies.
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Specifications

Form

Liquid

Additional notes

ab171708 is purified using conventional chromatography techniques.

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General info

Function

May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.

Sequence similarities

Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

Subcellular localisation

Mitochondrion

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Product protocols

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Target data

May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
See full target information OXSM
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Complementary Products

Primary Antibodies

AB229111

Anti-OXSM antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXSM antibody (AB229111)

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