Recombinant Human OXSM protein is a Human Full Length protein, in the 28 to 459 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S K R K F F G T V P I S R L H R R V V I T G I G L V T P L G V G T H L V W D R L I G G E S G I V S L V G E E Y K S I P C S V A A Y V P R G S D E G Q F N E Q N F V S K S D I K S M S S P T I M A I G A A E L A M K D S G W H P Q S E A D Q V A T G V A I G M G M I P L E V V S E T A L N F Q T K G Y N K V S P F F V P K I L V N M A A G Q V S I R Y K L K G P N H A V S T A C T T G A H A V G D S F R F I A H G D A D V M V A G G T D S C I S P L S L A G F S R A R A L S T N S D P K L A C R P F H P K R D G F V M G E G A A V L V L E E Y E H A V Q R R A R I Y A E V L G Y G L S G D A G H I T A P D P E G E G A L R C M A A A L K D A G V Q P E E I S Y I N A H A T S T P L G D A A E N K A I K H L F K D H A Y A L A V S S T K G A T G H L L G A A G A V E A A F T T L A C Y Y Q K L P P T L N L D C S E P E F D L N Y V P L K A Q E W K T E K R F I G L T N S F G F G G T N A T L C I A G L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
Alternative names
Beta-ketoacyl-ACP synthase, OXSM
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Recombinant Human OXSM protein is a Human Full Length protein, in the 28 to 459 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9NWU1-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S K R K F F G T V P I S R L H R R V V I T G I G L V T P L G V G T H L V W D R L I G G E S G I V S L V G E E Y K S I P C S V A A Y V P R G S D E G Q F N E Q N F V S K S D I K S M S S P T I M A I G A A E L A M K D S G W H P Q S E A D Q V A T G V A I G M G M I P L E V V S E T A L N F Q T K G Y N K V S P F F V P K I L V N M A A G Q V S I R Y K L K G P N H A V S T A C T T G A H A V G D S F R F I A H G D A D V M V A G G T D S C I S P L S L A G F S R A R A L S T N S D P K L A C R P F H P K R D G F V M G E G A A V L V L E E Y E H A V Q R R A R I Y A E V L G Y G L S G D A G H I T A P D P E G E G A L R C M A A A L K D A G V Q P E E I S Y I N A H A T S T P L G D A A E N K A I K H L F K D H A Y A L A V S S T K G A T G H L L G A A G A V E A A F T T L A C Y Y Q K L P P T L N L D C S E P E F D L N Y V P L K A Q E W K T E K R F I G L T N S F G F G G T N A T L C I A G L
- Accession
- Q9NWU1
- Protein length
- Full Length
- Predicted molecular weight
- 48.1 kDa
- Amino acids
- 28 to 459
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab171708 is purified using conventional chromatography techniques.
General info
- Function
May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
- Sequence similarities
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
- Subcellular localisation
- Mitochondrion
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
OXSM also known as 3-oxoacyl-[acyl-carrier-protein] synthase mitochondrial is an important enzyme in the mitochondrial fatty acid synthesis pathway. It participates in the elongation of fatty acids by catalyzing a ketoacyl synthesis reaction. This protein has a molecular mass of approximately 50 kDa. OXSM is mainly expressed in tissues with high metabolic activity such as liver and muscle tissues where it supports the dynamic balance of fatty acid synthesis.
- Biological function summary
OXSM plays a part in mitochondrial lipid homeostasis by facilitating the synthesis of longer chain fatty acids. It operates as part of a multiprotein complex that ensures proper substrate channeling and processing. This function is critical for the maintenance and functioning of cellular membranes providing the necessary lipid components. Additionally OXSM contributes to energy production by generating fatty acids that can be converted into acetyl-CoA units within the mitochondria.
- Pathways
Several metabolic pathways involve OXSM including the mitochondrial fatty acid synthesis and the broader lipid metabolism pathway. In the mitochondrial fatty acid synthesis pathway OXSM interacts with proteins like Acyl-CoA synthetase family member 1 (ACSF1) to facilitate the progression of fatty acid synthesis. These pathways collectively contribute to energy homeostasis and cellular membrane composition reflecting the interconnectivity between various metabolic functions.
- Associated diseases and disorders
Researchers associate OXSM with rare mitochondrial disorders linked to lipid metabolism. For instance mutations or dysfunctions in OXSM can result in compromised mitochondrial function potentially contributing to neuromuscular disorders. It also connects to carnitine palmitoyltransferase 1A (CPT1A) another key enzyme in fatty acid metabolism which highlights the interconnected nature of mitochondrial metabolic disorders. Understanding OXSM's role in these conditions can lead to better insights for therapeutic strategies.
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1 product image
SDS-PAGE - Recombinant Human OXSM protein (ab171708)
15% SDS-PAGE analysis of ab171708 (3μg).
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