Recombinant Human Oxytocin protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Oxytocin also known as the "love hormone" is a peptide consisting of nine amino acids with a molecular mass of approximately 1007 Daltons. It is synthesized in the hypothalamus and secreted by the posterior pituitary gland. Additionally oxytocin is expressed in other tissues including the uterus ovaries and even the heart. Its mechanical function involves binding to its receptor the oxytocin receptor (OXTR) which is a G-protein-coupled receptor and triggering intracellular signaling cascades that lead to calcium mobilization muscle contraction and other cellular responses.

Biological function summary

Oxytocin plays several significant roles in the body. It is involved in reproductive and social behaviors such as childbirth and lactation. During childbirth oxytocin induces uterine contractions facilitating the labor process. It also promotes milk ejection during breastfeeding by mediating the contraction of myoepithelial cells surrounding the mammary glands. Furthermore oxytocin contributes to social bonding and modulates emotional responses. It acts both in the central nervous system and peripherally affecting various physiological processes.

Pathways

Oxytocin is an important player in the neuroendocrine system especially in the pathways regulating labor and lactation. It functions closely with other neuropeptides and hormones such as vasopressin which also shares sequence homology and structural similarities. Oxytocin influences the MAPK/ERK signaling pathway which impacts cellular growth and differentiation. These pathways highlight oxytocin's role not only in reproductive events but also in the broader context of cell signaling networks within the body.

Oxytocin has links to conditions like autism spectrum disorders (ASD) and postpartum depression. Researchers suggest that alterations in oxytocin levels or its receptor function may contribute to social and emotional dysfunctions found in ASD. In postpartum depression abnormal oxytocin activities are thought to affect mood and emotional bonding between mother and child. Oxytocin interacts with other proteins like the serotonin receptor influencing mood regulation and emotional stability. Understanding oxytocin’s role in these disorders may lead to potential therapeutic strategies.