Recombinant Human p0071 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

P0071 also known as plakophilin-7 is a member of the armadillo family and exhibits a molecular mass of approximately 135 kDa. Mechanically p0071 functions as a scaffold protein by interconnecting cytoskeletal networks in cells. It predominantly expresses in epithelial and endothelial tissues where it localizes to cell-cell junctions and contributes to the structural integrity of cells. Having both armadillo repeats and a conserved domain indicative of its α-catenin interaction potential p0071 plays a mechanical role in supporting cellular architecture.

Biological function summary

Plakophilin-7 assists in the regulation of cell adhesion and signal transduction by interacting with desmosomal plaques. As part of this role p0071 associates with other junctional proteins to integrate into larger multiprotein complexes that define cell-cell contact. It reinforces desmosomes which are adhesive complexes required for strong intercellular connections critical for maintaining tissue integrity. p0071 influences the mechanical strength and resilience of tissues against external stress making it pivotal for normal epithelial and endothelial function.

Pathways

Interactions of plakophilin-7 have implications in the regulation of Wnt and Rho signaling pathways. p0071 partners with proteins such as beta-catenin and gamma-catenin in the Wnt signaling pathway influencing cell proliferation and differentiation. Additionally it connects to the Rho family GTPases pathway impacting cytoskeletal organization and cellular dynamics. Through these pathways p0071 orchestrates complex biological responses that are essential for cellular homeostasis and development.

Plakophilin-7 holds relevance in conditions like cancer and cardiovascular disease. Altered expression or functionality of p0071 associates with tumor progression and metastasis particularly influencing epithelial-mesenchymal transition processes. In cardiovascular disorders disruptions in p0071 expression affect heart tissue integrity through links with proteins such as desmoplakin and plakoglobin. Understanding p0071’s involvement in these diseases provides insights into potential therapeutic targets to modulate its function.