Recombinant Human P15RS protein (His tag N-Terminus)
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Recombinant Human P15RS protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 312 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
P15RS, RPRD1A, Regulation of nuclear pre-mRNA domain-containing protein 1A, Cyclin-dependent kinase inhibitor 2B-related protein, p15INK4B-related protein
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human P15RS protein (His tag N-Terminus) (AB180347)
15% SDS-PAGE analysis of ab180347 (3 μg)
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
P15RS regulates the interaction of proteins involved in apoptosis and cell survival serving as a modulator between these processes. It associates with complexes that control cell cycle transitions particularly at the G1/S checkpoint. This RNA interacts directly with proteins such as cyclin-dependent kinases affecting their activity and contributing to the balance between cell proliferation and arrest.
Pathways
This regulatory RNA operates within the p53 signaling pathway and participates in the control of cellular aging and apoptosis. It interacts with proteins like p21 and p27 which are key regulators in these processes. Through these interactions P15RS helps maintain the integrity of cellular mechanisms that govern cell growth and response to DNA damage playing a role in preventing unscheduled progression in the cell cycle.
Specifications
Form
Liquid
Additional notes
ab180347 was purified using conventional chromatography.
General info
Function
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
Sequence similarities
Belongs to the UPF0400 (RTT103) family.
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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