Recombinant Human p23 protein
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(1 Publication)
Recombinant Human p23 protein is a Human Full Length protein, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, WB.
View Alternative Names
P23, TEBP, PTGES3, Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, cPGES
- WB
Unknown
Western blot - Recombinant Human p23 protein (AB113183)
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Western blot - Recombinant Human p23 protein (ab113183) at 0.1 µg
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Antibody which recognises p23
true
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human p23 protein (AB113183)
ab113183, at 0.5μg in lane 1, 1μg in lane 2, 2μg in lane 3 and 5μg in lane 4, staining Human p23 using SDS-PAGE. Imperial stain used.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
P23 assists Hsp90 in protein-folding processes. As part of the Hsp90 chaperone complex p23 contributes to the correct folding and functioning of several essential client proteins. This chaperone activity is important for cellular processes like signal transduction and protein degradation. Without p23 Hsp90's efficiency in maintaining protein homeostasis can decrease highlighting the importance of their interaction in the cell.
Pathways
The chaperone actions of p23 extensively impact protein signaling pathways and stress response mechanisms. P23 and Hsp90 are important in the Akt/PI3K signaling pathway which regulates cell proliferation and survival. The complex formed by p23 and Hsp90 also involves heat shock proteins like Hsp70 which collaborates in broader cellular stress responses. These connections demonstrate how p23 integrates into cellular regulation and signal transduction networks.
Specifications
Form
Liquid
Additional notes
Purified by multi step chromatography
General info
Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed : 10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed : 11274138, PubMed : 12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed : 24711448).
Sequence similarities
Belongs to the p23/wos2 family.
Post-translational modifications
Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation.
Target data
Publications (1)
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Scientific reports 12:10568 PubMed35732702
2022
Applications
Unspecified application
Species
Unspecified reactive species
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Product promise
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