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AB174390

Recombinant Human P311 protein (His tag N-Terminus)

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Recombinant Human P311 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 68 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C5orf13, P311, NREP, Neuronal regeneration-related protein, Neuronal protein 3.1, Protein p311

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SDS-PAGE - Recombinant Human P311 protein (His tag N-Terminus) (AB174390)
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Supplier Data

SDS-PAGE - Recombinant Human P311 protein (His tag N-Terminus) (AB174390)

15% SDS-PAGE analysis of 3 μg ab174390.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q16612

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris-HCl buffer

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMVYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDETNAASLTPLGSSELRSPRISYLHFF","proteinLength":"Full Length","predictedMolecularWeight":"10.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":68,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q16612","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein P311 also known as PTZ17 or NREP (neuronal regeneration-related protein) plays a role in cell migration and tissue repair. It has a molecular mass of approximately 8 kDa. You can find P311 mainly in the brain though it is also present in other tissues like skin and lung. This protein acts by modulating the cytoskeletal organization which is essential for its functions in different types of cells.
Biological function summary

P311 affects cellular processes such as muscle regeneration and neuronal development. It does not form part of a larger protein complex but interacts directly with different signaling pathways aiding cell motility and growth. P311 keeps a high expression during the early stages of cell differentiation further showing its role in developmental biology.

Pathways

P311 fits into the transforming growth factor-beta (TGF-β) signaling pathway influencing wound healing and inflammatory responses. It interacts with proteins involved in this pathway such as TGF-β1 and SMAD proteins. P311 also modulates the Rho GTPase signaling pathway which controls actin cytoskeletal dynamics suggesting its importance in cell motility and morphology.

P311 shows relevance to conditions like cancer metastasis and fibrosis. Its upregulation links with increased metastatic potential in various cancer types. Furthermore P311 connects with TGF-β an important player in fibrotic diseases such as pulmonary fibrosis highlighting its impact on disease processes. Understanding P311's role in these conditions could provide new therapeutic targets for disease intervention and management.
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Specifications

Form

Liquid

Additional notes

ab174390 is purified using conventional chromatography.

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General info

Function

May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.

Post-translational modifications

Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.

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Product protocols

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Target data

May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.
See full target information NREP
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Complementary Products

Primary Antibodies

AB167017

Anti-P311 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P311 antibody (AB167017)

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Proteins & Peptides

AB177641

Recombinant Human XRCC2 protein (denatured) (His tag N-Terminus)

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