Recombinant Human PAC-2 protein is a Human Full Length protein, in the 1 to 264 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
M G S S H H H H H H S S G L V P R G S H M G S M F V P C G E S A P D L A G F T L L M P A V S V G N V G Q L A M D L I I S T L N M S K I G Y F Y T D C L V P M V G N N P Y A T T E G N S T E L S I N A E V Y S L P S R K L V A L Q L R S I F I K Y K S K P F C E K L L S W V K S S G C A R V I V L S S S H S Y Q R N D L Q L R S T P F R Y L L T P S M Q K S V Q N K I K S L N W E E M E K S R C I P E I D D S E F C I R I P G G G I T K T L Y D E S C S K E I Q M A V L L K F V S E G D N I P D A L G L V E Y L N E W L Q I L K P L S D D P T V S A S R W K I P S S W R L L F G S G L P P A L F
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
HCCA3, PAC2, TNFSF5IP1, TNFSF5IP1, PSMG2, PAC2, HCCA3, Proteasome assembly chaperone 2, PAC-2, Hepatocellular carcinoma-susceptibility protein 3, Tumor necrosis factor superfamily member 5-induced protein 1
Recombinant Human PAC-2 protein is a Human Full Length protein, in the 1 to 264 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
No
Human
pH: 8
Constituents: 40% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl
M G S S H H H H H H S S G L V P R G S H M G S M F V P C G E S A P D L A G F T L L M P A V S V G N V G Q L A M D L I I S T L N M S K I G Y F Y T D C L V P M V G N N P Y A T T E G N S T E L S I N A E V Y S L P S R K L V A L Q L R S I F I K Y K S K P F C E K L L S W V K S S G C A R V I V L S S S H S Y Q R N D L Q L R S T P F R Y L L T P S M Q K S V Q N K I K S L N W E E M E K S R C I P E I D D S E F C I R I P G G G I T K T L Y D E S C S K E I Q M A V L L K F V S E G D N I P D A L G L V E Y L N E W L Q I L K P L S D D P T V S A S R W K I P S S W R L L F G S G L P P A L F
Full Length
31.8 kDa
1 to 264
Recombinant
His tag N-Terminus
Liquid
ab113597 was purified using conventional chromatography.
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Belongs to the PSMG2 family.
Degraded by the proteasome upon completion of 20S proteasome maturation.
Nucleus
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
PAC-2 also known as PAC and Anti-PAC is a protein involved in various cellular processes. It appears important in apoptosis and the regulation of cellular proliferation. PAC-2 has an approximate mass of 40 kDa. Researchers have observed its expression in different tissues including the nervous system immune cells and several cancerous tissues. Understanding the mechanical functions of PAC-2 can offer insights into its role in cellular homeostasis and disease pathology.
PAC-2 plays an essential role in apoptosis acting as a mediator of programmed cell death. While not characterized as part of a larger complex PAC-2 interacts with other proteins to regulate cell survival and death. It likely influences the mitochondrial pathway of apoptosis by controlling cytochrome c release which is a critical step in the activation of caspases. These interactions emphasize the protein's adaptive importance in various biological contexts.
PAC-2 commands a significant presence in apoptotic signaling and cellular stress response pathways. It influences the intrinsic (mitochondrial) apoptotic pathway and may interact with proteins such as Bcl-2 family members and caspase-9. This interaction places PAC-2 in an important position where it can modify the balance between cell survival and cell death involving proteins that balance pro-apoptotic and anti-apoptotic signals.
PAC-2 has correlations with cancer and neurodegenerative diseases. Its dysregulation in certain cancers suggests a role in tumor progression and resistance to apoptosis. The connection to Bcl-2 highlights this aspect as both are involved in the suppression of cell death. In neurodegenerative diseases like Alzheimer's altered PAC-2 function might contribute to the pathological accumulation of damaged cells influenced by its effect on apoptotic pathways. Understanding these links could advance therapeutic strategies for related conditions.
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15% SDS-PAGE analysis of ab113597 (3μg)
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