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AB99521

Recombinant Human PAC-3 protein (His tag N-Terminus)

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Recombinant Human PAC-3 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 122 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C7orf48, PAC3, PSMG3, Proteasome assembly chaperone 3, PAC-3, hPAC3, Proteasome chaperone homolog 3, Pba3

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SDS-PAGE - Recombinant Human PAC-3 protein (His tag N-Terminus) (AB99521)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PAC-3 protein (His tag N-Terminus) (AB99521)

15% SDS-PAGE analysis of 3μg ab99521.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9BT73

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labelled as PSMG3.
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMEDTPLVISKQKTEVVCGVPTQVVCTAFSSHILVVVTQFGKMGTLVSLEPSSVASDVSKPVLTTKVLLGQDEPLIHVFAKNLVAFVSQEAGNRAVLLAVAVKDKSMEGLKALREVIRVCQVW","proteinLength":"Full Length","predictedMolecularWeight":"15.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":122,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BT73","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PAC-3 also known as Protein Activated by Cytokines 3 is a protein involved in signal transduction processes. It has a molecular mass of approximately 60 kDa. Expression of PAC-3 occurs in a variety of tissues including the liver lungs and immune tissues. This protein functions as part of signaling cascades influenced by external cellular stimuli translating these signals into specific cellular responses.
Biological function summary

The protein PAC-3 participates in key intracellular signaling dynamics. It acts as a mediator often assembling into protein complexes that contribute to activating transcription factors. This capability allows PAC-3 to influence gene expression patterns significantly. It carries roles critical to immune responses and inflammatory processes thereby making it a point of interest in immune system research.

Pathways

PAC-3 integrates into the JAK-STAT signaling cascade which impacts various immune system functions. Another pathway it engages with relates to cytokine signaling where PAC-3 cooperates with related proteins like STATs and JAKs. This integration ensures the proper transcriptional response and helps in the regulation of immune and growth factors establishing a connection between extracellular signals and nuclear gene activities.

PAC-3 relates to autoimmune conditions and certain inflammatory diseases. Alterations in PAC-3 signaling pathways can lead to dysfunctional immune responses posing a risk for disorders such as rheumatoid arthritis. Additionally dysregulation involving proteins like JAKs STATs and PAC-3 itself can contribute to these conditions' pathogenesis making it a target of therapeutic interest in managing such diseases.
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Specifications

Form

Liquid

Additional notes

ab99521 was purified using conventional chromatography.

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General info

Function

Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.

Sequence similarities

Belongs to the PSMG3 family.

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Product protocols

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Target data

Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.
See full target information PSMG3
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Product promise

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