Recombinant Human PAC-3 protein is a Human Full Length protein, in the 1 to 122 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M E D T P L V I S K Q K T E V V C G V P T Q V V C T A F S S H I L V V V T Q F G K M G T L V S L E P S S V A S D V S K P V L T T K V L L G Q D E P L I H V F A K N L V A F V S Q E A G N R A V L L A V A V K D K S M E G L K A L R E V I R V C Q V W
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.
Alternative names
C7orf48, PAC3, PSMG3, Proteasome assembly chaperone 3, PAC-3, hPAC3, Proteasome chaperone homolog 3, Pba3
Recommended products
Recombinant Human PAC-3 protein is a Human Full Length protein, in the 1 to 122 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9BT73-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M E D T P L V I S K Q K T E V V C G V P T Q V V C T A F S S H I L V V V T Q F G K M G T L V S L E P S S V A S D V S K P V L T T K V L L G Q D E P L I H V F A K N L V A F V S Q E A G N R A V L L A V A V K D K S M E G L K A L R E V I R V C Q V W
- Accession
- Q9BT73
- Protein length
- Full Length
- Predicted molecular weight
- 15.2 kDa
- Amino acids
- 1 to 122
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab99521 was purified using conventional chromatography.
General info
- Function
Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.
- Sequence similarities
Belongs to the PSMG3 family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Previously labelled as PSMG3.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PAC-3 also known as Protein Activated by Cytokines 3 is a protein involved in signal transduction processes. It has a molecular mass of approximately 60 kDa. Expression of PAC-3 occurs in a variety of tissues including the liver lungs and immune tissues. This protein functions as part of signaling cascades influenced by external cellular stimuli translating these signals into specific cellular responses.
- Biological function summary
The protein PAC-3 participates in key intracellular signaling dynamics. It acts as a mediator often assembling into protein complexes that contribute to activating transcription factors. This capability allows PAC-3 to influence gene expression patterns significantly. It carries roles critical to immune responses and inflammatory processes thereby making it a point of interest in immune system research.
- Pathways
PAC-3 integrates into the JAK-STAT signaling cascade which impacts various immune system functions. Another pathway it engages with relates to cytokine signaling where PAC-3 cooperates with related proteins like STATs and JAKs. This integration ensures the proper transcriptional response and helps in the regulation of immune and growth factors establishing a connection between extracellular signals and nuclear gene activities.
- Associated diseases and disorders
PAC-3 relates to autoimmune conditions and certain inflammatory diseases. Alterations in PAC-3 signaling pathways can lead to dysfunctional immune responses posing a risk for disorders such as rheumatoid arthritis. Additionally dysregulation involving proteins like JAKs STATs and PAC-3 itself can contribute to these conditions' pathogenesis making it a target of therapeutic interest in managing such diseases.
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1 product image
SDS-PAGE - Recombinant Human PAC-3 protein (ab99521)
15% SDS-PAGE analysis of 3μg ab99521.
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