Recombinant Human PACE4 protein is a Human Fragment protein, in the 860 to 969 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
R E E C I H C A K N F H F H D W K C V P A C G E G F Y P E E M P G L P H K V C R R C D E N C L S C A G S S R N C S R C K T G F T Q L G T S C I T N H T C S N A D E T F C E M V K S N R L C E R K L F I Q F C C R T C L L A G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes Recombinant protein. |
Target data
Function
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.
Alternative names
PACE4, PCSK6, Proprotein convertase subtilisin/kexin type 6, Paired basic amino acid cleaving enzyme 4, Subtilisin-like proprotein convertase 4, Subtilisin/kexin-like protease PACE4, SPC4
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Recombinant Human PACE4 protein is a Human Fragment protein, in the 860 to 969 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P29122-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
Sequence info
Amino acid sequence
- R E E C I H C A K N F H F H D W K C V P A C G E G F Y P E E M P G L P H K V C R R C D E N C L S C A G S S R N C S R C K T G F T Q L G T S C I T N H T C S N A D E T F C E M V K S N R L C E R K L F I Q F C C R T C L L A G
- Accession
- P29122
- Protein length
- Fragment
- Predicted molecular weight
- 37.73 kDa
- Amino acids
- 860 to 969
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.
- Sequence similarities
Belongs to the peptidase S8 family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PACE4 also known as PCSK6 is a member of the proprotein convertase family that functions mechanically as a serine endoprotease. This protein plays a role in cleaving precursors of hormones and other proteins to activate their bioactive forms. PACE4 has a molecular mass of approximately 97 kDa. It is expressed in various tissues including the brain pituitary gland and reproductive organs indicative of its involvement in diverse physiological processes.
- Biological function summary
PACE4 participates in cellular and developmental processes by processing precursors into active proteins. It is part of a complex of proprotein convertases responsible for the maturation of secretory pathway proteins. PACE4 takes part in the regulation of growth factors matrix metalloproteinases and adhesion molecules exerting influence on cellular growth and development as well as extracellular matrix remodeling.
- Pathways
PACE4 involves itself in specific signaling pathways integral to the activation of precursor proteins. It prominently participates in the TGF-beta signaling pathway where it activates transforming growth factor-beta precursors. PACE4 also acts in pathways implicated in the release of active forms of proteins such as integrins and collagens working alongside related convertases such as furin which shares overlapping substrate specificity.
- Associated diseases and disorders
PACE4 contribution links to pathological processes in certain cancers and osteoarthritis through its regulation of tumor growth and cartilage degradation respectively. In cancer PACE4 activates matrix metalloproteinases that aid tumor invasion and metastasis. Its relation with cancer involves interactions with other proteins like MMP-2 enhancing the potential for cellular invasiveness. In osteoarthritis PACE4's influence on cartilage tissue involves connections with ADAMTSs impacting cartilage matrix composition and health.
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1 product image
SDS-PAGE - Recombinant Human PACE4 protein (ab114961)
12.5% SDS-PAGE showing ab114961 at approximately 37.73kDa.
Stained with Coomassie Blue.
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