Recombinant Human PACS2 protein is a Human Full Length protein, in the 1 to 889 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M A E R G R L G L P G A P G A L N T P V P M N L F A T W E V D G S S P S C V P R L C S L T L K K L V V F K E L E K E L I S V V I A V K M Q G S K R I L R S H E I V L P P S G Q V E T D L A L T F S L Q Y P H F L K R E G N K L Q I M L Q R R K R Y K N R T I L G Y K T L A A G S I S M A E V M Q H P S E G G Q V L S L C S S I K E A P V K A A D I W I A S L S S Q P I D H E D S T M Q A G P K A K S T D N Y S E E E Y E S F S S E Q E A S D D A V Q G Q D L D E D D F D V G K P K K Q R R S I V R T T S M T R Q Q N F K Q K V V A L L R R F K V S G E V L D S E Q D P A E H I P E A E E D L D L L Y D T L D M E H P S D S G P D M E D D D S V L S T P K P K L R P Y F E G L S H S S S Q T E I G S I H S A R S H K E P P S P A D V P E K T R S L G G R Q P S D S V S D T V A L G V P G P R E H P G Q P E D S P E A E A S T L D V F T E R L P P S G R I T K T E S L V I P S T R S E G K Q A G R R G R S T S L K E R Q A A R P Q N E R A N S L D N E R C P D A R S Q L Q I H R K T V Y D Q L N D I L I S D D Q L P E N I I L V N T S D W Q G Q F L S D V L Q R H T L P V V C T C S P A D V Q A A F S T I V S R I Q R Y C N C N S Q P P T P V K I A V A G A Q H Y L S A I L R L F V E Q L S H K T P D W L G Y M R F L V I P L G S H P V A R Y L G S V D Y R Y N N F F Q D L A W R D L F N K L E A Q S A V Q D T P D I V S R I T Q Y I A G A N C A H Q L P I A E A M L T Y K Q K S P D E E S S Q K F I P F V G V V K V G I V E P S S A T S G D S D D A A P S G S G T L S S T P P S A S P A A K E A S P T P P S S P S V S G G L S S P S Q G V G A E L M G L Q V D Y W T A A Q P A D R K R D A E K K D L P V T K N T L K C T F R S L Q V S R L P S S G E A A A T P T M S M T V V T K E K N K K V M F L P K K A K D K D V E S K S Q C I E G I S R L I C T A R Q Q Q N M L R V L I D G V E C S D V K F F Q L A A Q W S S H V K H F P I C I F G H S K A T F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Alternative names
KIAA0602, PACS1L, PACS2, Phosphofurin acidic cluster sorting protein 2, PACS-2, PACS1-like protein
Recommended products
Recombinant Human PACS2 protein is a Human Full Length protein, in the 1 to 889 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q86VP3-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A E R G R L G L P G A P G A L N T P V P M N L F A T W E V D G S S P S C V P R L C S L T L K K L V V F K E L E K E L I S V V I A V K M Q G S K R I L R S H E I V L P P S G Q V E T D L A L T F S L Q Y P H F L K R E G N K L Q I M L Q R R K R Y K N R T I L G Y K T L A A G S I S M A E V M Q H P S E G G Q V L S L C S S I K E A P V K A A D I W I A S L S S Q P I D H E D S T M Q A G P K A K S T D N Y S E E E Y E S F S S E Q E A S D D A V Q G Q D L D E D D F D V G K P K K Q R R S I V R T T S M T R Q Q N F K Q K V V A L L R R F K V S G E V L D S E Q D P A E H I P E A E E D L D L L Y D T L D M E H P S D S G P D M E D D D S V L S T P K P K L R P Y F E G L S H S S S Q T E I G S I H S A R S H K E P P S P A D V P E K T R S L G G R Q P S D S V S D T V A L G V P G P R E H P G Q P E D S P E A E A S T L D V F T E R L P P S G R I T K T E S L V I P S T R S E G K Q A G R R G R S T S L K E R Q A A R P Q N E R A N S L D N E R C P D A R S Q L Q I H R K T V Y D Q L N D I L I S D D Q L P E N I I L V N T S D W Q G Q F L S D V L Q R H T L P V V C T C S P A D V Q A A F S T I V S R I Q R Y C N C N S Q P P T P V K I A V A G A Q H Y L S A I L R L F V E Q L S H K T P D W L G Y M R F L V I P L G S H P V A R Y L G S V D Y R Y N N F F Q D L A W R D L F N K L E A Q S A V Q D T P D I V S R I T Q Y I A G A N C A H Q L P I A E A M L T Y K Q K S P D E E S S Q K F I P F V G V V K V G I V E P S S A T S G D S D D A A P S G S G T L S S T P P S A S P A A K E A S P T P P S S P S V S G G L S S P S Q G V G A E L M G L Q V D Y W T A A Q P A D R K R D A E K K D L P V T K N T L K C T F R S L Q V S R L P S S G E A A A T P T M S M T V V T K E K N K K V M F L P K K A K D K D V E S K S Q C I E G I S R L I C T A R Q Q Q N M L R V L I D G V E C S D V K F F Q L A A Q W S S H V K H F P I C I F G H S K A T F
- Accession
- Q86VP3
- Protein length
- Full Length
- Amino acids
- 1 to 889
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
- Sequence similarities
Belongs to the PACS family.
- Subcellular localisation
- Mitochondrion
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PACS2 also known as Phosphofurin Acidic Cluster Sorting Protein 2 functions as an integral membrane-associated sorting protein within cells. It weighs approximately 102 kDa. The protein is expressed widely with specific presence noted in the cytoplasm and mitochondria. Its role predominantly lies in modulating the trafficking and localization of various proteins contributing to cellular homeostasis and maintenance.
- Biological function summary
PACS2 regulates cellular death pathways and mitochondrial dynamics by balancing pro- and anti-apoptotic signals. It forms part of the larger regulatory complexes that modulate interactions between organelles particularly affecting endoplasmic reticulum-mitochondria communication. This regulation influences apoptosis autophagy and calcium signaling playing an important role in cellular health and stress responses.
- Pathways
The PACS2 protein plays significant roles in pathways such as calcium homeostasis and the mitochondrial apoptosis pathway. It interacts with proteins like Bax and Bak which are essential for apoptotic processes. PACS2's function directly impacts cellular survival pathways by modulating calcium transfer between the endoplasmic reticulum and mitochondria showing its importance in signal transduction and energy metabolism.
- Associated diseases and disorders
PACS2 is connected to neurodegenerative diseases such as Alzheimer's disease and metabolic disorders like diabetes. In Alzheimer's the protein's dysregulation affects mitochondrial function and neuronal survival implicating it in the pathogenesis. It also interacts with proteins such as amyloid precursor protein in Alzheimer's highlighting its role in neurodegenerative disease processes. In diabetes altered PACS2 activity affects insulin signaling and mitochondrial function making it a potential target for therapeutic interventions.
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1 product image
SDS-PAGE - Recombinant Human PACS2 protein (ab161579)
ab161579 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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