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AB161579

Recombinant Human PACS2 protein (GST tag N-Terminus)

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Recombinant Human PACS2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 889 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA0602, PACS1L, PACS2, Phosphofurin acidic cluster sorting protein 2, PACS-2, PACS1-like protein

1 Images
SDS-PAGE - Recombinant Human PACS2 protein (GST tag N-Terminus) (AB161579)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PACS2 protein (GST tag N-Terminus) (AB161579)

ab161579 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q86VP3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB222316

Anti-PACS2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-PACS2 antibody (AB222316)

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Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Proteins & Peptides

AB159787

Recombinant Human UQCRFS1/RISP protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human UQCRFS1/RISP protein (GST tag N-Terminus) (AB159787)

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Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 691 (GST tag N-Terminus) (AB162402)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVETDLALTFSLQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSISMAEVMQHPSEGGQVLSLCSSIKEAPVKAADIWIASLSSQPIDHEDSTMQAGPKAKSTDNYSEEEYESFSSEQEASDDAVQGQDLDEDDFDVGKPKKQRRSIVRTTSMTRQQNFKQKVVALLRRFKVSGEVLDSEQDPAEHIPEAEEDLDLLYDTLDMEHPSDSGPDMEDDDSVLSTPKPKLRPYFEGLSHSSSQTEIGSIHSARSHKEPPSPADVPEKTRSLGGRQPSDSVSDTVALGVPGPREHPGQPEDSPEAEASTLDVFTERLPPSGRITKTESLVIPSTRSEGKQAGRRGRSTSLKERQAARPQNERANSLDNERCPDARSQLQIHRKTVYDQLNDILISDDQLPENIILVNTSDWQGQFLSDVLQRHTLPVVCTCSPADVQAAFSTIVSRIQRYCNCNSQPPTPVKIAVAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSAVQDTPDIVSRITQYIAGANCAHQLPIAEAMLTYKQKSPDEESSQKFIPFVGVVKVGIVEPSSATSGDSDDAAPSGSGTLSSTPPSASPAAKEASPTPPSSPSVSGGLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDLPVTKNTLKCTFRSLQVSRLPSSGEAAATPTMSMTVVTKEKNKKVMFLPKKAKDKDVESKSQCIEGISRLICTARQQQNMLRVLIDGVECSDVKFFQLAAQWSSHVKHFPICIFGHSKATF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":889,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86VP3","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PACS2 also known as Phosphofurin Acidic Cluster Sorting Protein 2 functions as an integral membrane-associated sorting protein within cells. It weighs approximately 102 kDa. The protein is expressed widely with specific presence noted in the cytoplasm and mitochondria. Its role predominantly lies in modulating the trafficking and localization of various proteins contributing to cellular homeostasis and maintenance.
Biological function summary

PACS2 regulates cellular death pathways and mitochondrial dynamics by balancing pro- and anti-apoptotic signals. It forms part of the larger regulatory complexes that modulate interactions between organelles particularly affecting endoplasmic reticulum-mitochondria communication. This regulation influences apoptosis autophagy and calcium signaling playing an important role in cellular health and stress responses.

Pathways

The PACS2 protein plays significant roles in pathways such as calcium homeostasis and the mitochondrial apoptosis pathway. It interacts with proteins like Bax and Bak which are essential for apoptotic processes. PACS2's function directly impacts cellular survival pathways by modulating calcium transfer between the endoplasmic reticulum and mitochondria showing its importance in signal transduction and energy metabolism.

PACS2 is connected to neurodegenerative diseases such as Alzheimer's disease and metabolic disorders like diabetes. In Alzheimer's the protein's dysregulation affects mitochondrial function and neuronal survival implicating it in the pathogenesis. It also interacts with proteins such as amyloid precursor protein in Alzheimer's highlighting its role in neurodegenerative disease processes. In diabetes altered PACS2 activity affects insulin signaling and mitochondrial function making it a potential target for therapeutic interventions.
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Specifications

Form

Liquid

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General info

Function

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

Sequence similarities

Belongs to the PACS family.

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Product protocols

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Target data

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
See full target information PACS2
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Product promise

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