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AB126915

Recombinant Human PADI6 protein

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Recombinant Human PADI6 protein is a Human Full Length protein, in the 1 to 686 aa range, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE.

View Alternative Names

PAD6, PADI6, Protein-arginine deiminase type-6, Peptidyl arginine deiminase-like protein, Peptidylarginine deiminase VI, Protein-arginine deiminase type VI, hPADVI

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SDS-PAGE - Recombinant Human PADI6 protein (AB126915)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PADI6 protein (AB126915)

SDS-PAGE analysis of ab126915.

Key facts

Purity

>95% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q6TGC4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"100 kDa","actualMolecularWeight":null,"aminoAcidEnd":686,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q6TGC4","tags":[]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PADI6 also known as Peptidylarginine Deiminase 6 is an enzyme that belongs to the peptidylarginine deiminase family. It plays an important role in the process of protein deimination converting arginine residues into citrulline in a calcium-dependent manner. The molecular weight of PADI6 is approximately 76 kDa. This protein is primarily expressed in oocytes and early embryos where it exerts its functions in the cytoplasm.
Biological function summary

PADI6 influences cellular structures and signaling pathways associated with oocyte maturation and early embryonic development. It forms part of the cytoplasmic lattice complex a structure contributing to the regulation of maternal RNA stability and storage. This protein affects various processes necessary for embryo development acting as a regulator by modulating proteins involved in these events.

Pathways

Regulation of gene expression and cytoskeletal organization involves PADI6 activity. It participates in signaling pathways critical for embryo development. During these processes PADI6 may interact with other proteins such as tubulins and histones reflecting its involvement in broader cellular functions and structural regulation.

Defective PADI6 activity associates with reproductive health issues including early embryonic arrest and female infertility. Its role in these conditions often links to its regulatory influence on proteins like tubulins essential for cytoskeletal organization. These dysfunctions highlight its importance in proper cellular architecture and early developmental processes.
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Specifications

Form

Liquid

Additional notes

Assessed by densitometry. Affinity purified.

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General info

Function

Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed : 27545678).. Catalyzes the deimination of arginine residues of proteins (By similarity). In oocytes, is released during cortical reaction and plays a role in preimplantation cleavage and early embryonic development (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed : 27545678).

Sequence similarities

Belongs to the protein arginine deiminase family.

Post-translational modifications

Phosphorylation at Ser-10, possibly by RSK-type kinases, and Ser-446 creates binding sites for 14-3-3 proteins.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed : 27545678).. Catalyzes the deimination of arginine residues of proteins (By similarity). In oocytes, is released during cortical reaction and plays a role in preimplantation cleavage and early embryonic development (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed : 27545678).
See full target information PADI6
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