Recombinant Human PAF-1 protein
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Recombinant Human PAF-1 protein is a Human Full Length protein, in the 1 to 305 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
PAF1, PMP3, PMP35, PXMP3, RNF72, PEX2, Peroxisome biogenesis factor 2, 35 kDa peroxisomal membrane protein, Peroxin-2, Peroxisomal membrane protein 3, Peroxisome assembly factor 1, RING finger protein 72, PAF-1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human PAF-1 protein (AB159291)
ab159291 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Specifications
Form
Liquid
General info
Function
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed : 24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity). PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel : catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity). Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 (PubMed : 27597759). Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (PubMed : 34903883).
Sequence similarities
Belongs to the pex2/pex10/pex12 family.
Post-translational modifications
Forms intramolecular and intermolecular disulfide bonds in response to reactive oxygen species (ROS), promoting higher stability.
Subcellular localisation
Peroxisome membrane
Target data
Complementary Products
Product promise
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