Recombinant human PAK5 protein
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(1 Publication)
Recombinant human PAK5 protein is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with >75%, suitable for SDS-PAGE, FuncS.
View Alternative Names
KIAA1264, PAK7, PAK5, Serine/threonine-protein kinase PAK 5, p21-activated kinase 5, p21-activated kinase 7, PAK-5, PAK-7
- FuncS
Unknown
Functional Studies - Recombinant human PAK5 protein (AB60754)
Sample Kinase Activity Plot.
- FuncS
Unknown
Functional Studies - Recombinant human PAK5 protein (AB60754)
The specific activity of PAK5 (ab60754) was determined to be 14 nmol/min/mg as per activity assay protocol and was equivalent to 60 nmol/min/mg as per radiometric assay
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human PAK5 protein (AB60754)
ab60754 on SDS-PAGE, MW ~130kDa.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human PAK5 protein (AB60754)
SDS PAGE analysis of ab60754
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Post-translational modifications
Autophosphorylated when activated by CDC42/p21.
Subcellular localisation
Mitochondrion
Target data
Publications (1)
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Clinical and translational medicine 12:e1113 PubMed36394206
2022
Applications
Unspecified application
Species
Unspecified reactive species
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Product promise
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