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AB124579

Recombinant Human Pallidin protein (His tag N-Terminus)

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Recombinant Human Pallidin protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 172 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

PA, PLDN, BLOC1S6, Biogenesis of lysosome-related organelles complex 1 subunit 6, BLOC-1 subunit 6, Pallid protein homolog, Pallidin, Syntaxin 13-interacting protein

1 Images
SDS-PAGE - Recombinant Human Pallidin protein (His tag N-Terminus) (AB124579)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Pallidin protein (His tag N-Terminus) (AB124579)

15% SDS-PAGE showing ab124579 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9UL45

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMSVPGPSSPDGALTRPPYCLEAGEPTPGLSDTSPDEGLIEDLTIEDKAVEQLAEGLLSHYLPDLQRSKQALQELTQNQVVLLDTLEQEISKFKECHSMLDINALFAEAKHYHAKLVNIRKEMLMLHEKTSKLKKRALKLQQKRQKEELEREQQREKEFEREKQLTARPAKRM","proteinLength":"Full Length","predictedMolecularWeight":"21.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":172,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UL45","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Pallidin also known as Pldn is a protein that plays a part in the biogenesis of lysosome-related organelles. It has a molecular mass of approximately 11 kDa. Pallidin expresses mostly in tissues like lungs skin and hematopoietic cells. It associates with the endosomal and lysosomal compartments where it participates in protein trafficking and organelle maturation.
Biological function summary

Pallidin functions as a part of the BLOC-1 (Biogenesis of Lysosome-related Organelles Complex-1) multiprotein complex. This complex aids in the formation and function of pigment granules platelet dense granules and other lysosome-related organelles. Pallidin works by stabilizing the BLOC-1 complex and interacting with other proteins within the lysosomal trafficking route which is important for maintaining normal cell functions.

Pathways

Pallidin resides within the endosomal-lysosomal pathway and is essential for proper vesicular trafficking. Pallidin interacts with proteins such as Snapin and Dysbindin both of which contribute to the regulation of intracellular endosome transport. These interactions help coordinate the delivery of membrane proteins and lipids to distinct vesicular compartments within the cell supporting cellular communication and function.

Pallidin has a connection with Hermansky-Pudlak syndrome type 2 a genetic disorder affecting lysosomal related organelles. This condition leads to albinism bleeding disorders and lung fibrosis due to defects in BLOC-1 complex function. Pallidin's involvement in this syndrome ties closely with other BLOC-1 components like Dysbindin revealing genetic interactions that influence phenotypic expression and provide insight into targeted therapies for related disorders.
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Specifications

Form

Liquid

Additional notes

ab124579 is purified using conventional chromatography techniques.

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General info

Function

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

Sequence similarities

Belongs to the BLOC1S6 family.

Post-translational modifications

Phosphorylated.

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Product protocols

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Target data

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
See full target information BLOC1S6
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Product promise

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