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AB159181

Recombinant Human Papillary renal cell carcinoma protein (GST tag N-Terminus)

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Recombinant Human Papillary renal cell carcinoma protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 491 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

TPRC, PRCC, Proline-rich protein PRCC, Papillary renal cell carcinoma translocation-associated gene protein

1 Images
SDS-PAGE - Recombinant Human Papillary renal cell carcinoma protein (GST tag N-Terminus) (AB159181)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Papillary renal cell carcinoma protein (GST tag N-Terminus) (AB159181)

ab159181 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q92733

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB86602

Anti-Papillary renal cell carcinoma antibody

Immunoprecipitation - Anti-Papillary renal cell carcinoma antibody (AB86602)

  • 0
  • 0
Primary Antibodies

AB109379

Anti-RCC1 antibody [EPR5857]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-RCC1 antibody [EPR5857] (AB109379)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Proteins & Peptides

AB131742

Recombinant Human XRCC1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human XRCC1 protein (GST tag N-Terminus) (AB131742)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSLVAYASSDESEPDEAEPEPEEEEAVAPTSGPALGGLFASLPAPKGPALLPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGFPPPPGVSPAEAAGVGEGLGLGLPSPRGPGLNLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDSDSEEDEPTKKKTILQGSSEGTGLSALLPQPKNLTVKETNRLLLPHAFSRKPSDGSPDTKPSRLASKTKTSSLAPVVGTTTTTPSPSAIKAAAKSAALQVTKQITQEEDDSDEEVAPENFFSLPEKAEPPGVEPYPYPIPTVPEELPPGTEPEPAFQDDAANAPLEFKMAAGSSGAPWMPKPGDDYSYNQFSTYGDANAAGAYYQDYYSGGYYPAQDPALVPTQEIAPDASFIDDEAFKRLQGKRNRGREEINFVEIKGDDQLSGAQQWMTKSLTEEKTMKSFSKKKGEQPTGQQRRKHQITYLIHQAKERELELKNTWSENKLSRRQTQAKYGF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":491,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q92733","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Papillary renal cell carcinoma (PRCC) also known as papillary renal is a significant variant of kidney cancer. It arises mechanically from the epithelial cells of the kidney tubules that exhibit papillary growth patterns. PRCC lacks a single protein target but involves various changes on the molecular level often linked to genetic alterations such as mutations in the MET oncogene. These changes can affect cell surface expression and signal pathways. The mass or size data about individual protein targets in this context is not typically described due to the complex and multi-genetic nature of PRCC.
Biological function summary

PRCC forms as a type of cancer characterized by the formation of finger-like projections in the kidney. It does not align to a single protein or simple biological function but involves components like alterations in the MET pathway an independent complex soliciting increased proliferative and migratory signals within renal tissues. This process can lead to the unusual cell growth that distinguishes PRCC in affected kidneys.

Pathways

MET signaling pathway and the associated HGF (hepatocyte growth factor) signaling cascade are closely involved in papillary renal phenotypes. These pathways contribute significantly to cell growth migration and differentiation regulation within the renal system. It's related to proteins such as RAS and PI3K which play essential roles in further amplifying cellular signals that contribute to oncogenesis.

PRCC is closely linked to kidney cancer specifically identified in renal cell carcinoma spectrum. Genetic evidence connects PRCC to von Hippel-Lindau (VHL) disease a disorder known to predispose individuals to various tumors. The VHL protein exhibits abnormal function in both VHL disease and PRCC highlighting its role in disease progression and potential as a therapeutic target. Additionally the involvement of the MET protein stands out as a specific player in familial cases of PRCC contributing to an inherited predisposition to this type of cancer.
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Specifications

Form

Liquid

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General info

Function

May regulate cell cycle progression through interaction with MAD2L2.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May regulate cell cycle progression through interaction with MAD2L2.
See full target information PRCC
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