Recombinant Human Papillary renal cell carcinoma protein is a Human Full Length protein, in the 1 to 491 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M S L V A Y A S S D E S E P D E A E P E P E E E E A V A P T S G P A L G G L F A S L P A P K G P A L L P P P P Q M L A P A F P P P L L L P P P T G D P R L Q P P P P L P F G L G G F P P P P G V S P A E A A G V G E G L G L G L P S P R G P G L N L P P P I G G A G P P L G L P K P K K R K E P V K I A A P E L H K G D S D S E E D E P T K K K T I L Q G S S E G T G L S A L L P Q P K N L T V K E T N R L L L P H A F S R K P S D G S P D T K P S R L A S K T K T S S L A P V V G T T T T T P S P S A I K A A A K S A A L Q V T K Q I T Q E E D D S D E E V A P E N F F S L P E K A E P P G V E P Y P Y P I P T V P E E L P P G T E P E P A F Q D D A A N A P L E F K M A A G S S G A P W M P K P G D D Y S Y N Q F S T Y G D A N A A G A Y Y Q D Y Y S G G Y Y P A Q D P A L V P T Q E I A P D A S F I D D E A F K R L Q G K R N R G R E E I N F V E I K G D D Q L S G A Q Q W M T K S L T E E K T M K S F S K K K G E Q P T G Q Q R R K H Q I T Y L I H Q A K E R E L E L K N T W S E N K L S R R Q T Q A K Y G F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May regulate cell cycle progression through interaction with MAD2L2.
Alternative names
TPRC, PRCC, Proline-rich protein PRCC, Papillary renal cell carcinoma translocation-associated gene protein
Recommended products
Recombinant Human Papillary renal cell carcinoma protein is a Human Full Length protein, in the 1 to 491 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q92733-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M S L V A Y A S S D E S E P D E A E P E P E E E E A V A P T S G P A L G G L F A S L P A P K G P A L L P P P P Q M L A P A F P P P L L L P P P T G D P R L Q P P P P L P F G L G G F P P P P G V S P A E A A G V G E G L G L G L P S P R G P G L N L P P P I G G A G P P L G L P K P K K R K E P V K I A A P E L H K G D S D S E E D E P T K K K T I L Q G S S E G T G L S A L L P Q P K N L T V K E T N R L L L P H A F S R K P S D G S P D T K P S R L A S K T K T S S L A P V V G T T T T T P S P S A I K A A A K S A A L Q V T K Q I T Q E E D D S D E E V A P E N F F S L P E K A E P P G V E P Y P Y P I P T V P E E L P P G T E P E P A F Q D D A A N A P L E F K M A A G S S G A P W M P K P G D D Y S Y N Q F S T Y G D A N A A G A Y Y Q D Y Y S G G Y Y P A Q D P A L V P T Q E I A P D A S F I D D E A F K R L Q G K R N R G R E E I N F V E I K G D D Q L S G A Q Q W M T K S L T E E K T M K S F S K K K G E Q P T G Q Q R R K H Q I T Y L I H Q A K E R E L E L K N T W S E N K L S R R Q T Q A K Y G F
- Accession
- Q92733
- Protein length
- Full Length
- Amino acids
- 1 to 491
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May regulate cell cycle progression through interaction with MAD2L2.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Papillary renal cell carcinoma (PRCC) also known as papillary renal is a significant variant of kidney cancer. It arises mechanically from the epithelial cells of the kidney tubules that exhibit papillary growth patterns. PRCC lacks a single protein target but involves various changes on the molecular level often linked to genetic alterations such as mutations in the MET oncogene. These changes can affect cell surface expression and signal pathways. The mass or size data about individual protein targets in this context is not typically described due to the complex and multi-genetic nature of PRCC.
- Biological function summary
PRCC forms as a type of cancer characterized by the formation of finger-like projections in the kidney. It does not align to a single protein or simple biological function but involves components like alterations in the MET pathway an independent complex soliciting increased proliferative and migratory signals within renal tissues. This process can lead to the unusual cell growth that distinguishes PRCC in affected kidneys.
- Pathways
MET signaling pathway and the associated HGF (hepatocyte growth factor) signaling cascade are closely involved in papillary renal phenotypes. These pathways contribute significantly to cell growth migration and differentiation regulation within the renal system. It's related to proteins such as RAS and PI3K which play essential roles in further amplifying cellular signals that contribute to oncogenesis.
- Associated diseases and disorders
PRCC is closely linked to kidney cancer specifically identified in renal cell carcinoma spectrum. Genetic evidence connects PRCC to von Hippel-Lindau (VHL) disease a disorder known to predispose individuals to various tumors. The VHL protein exhibits abnormal function in both VHL disease and PRCC highlighting its role in disease progression and potential as a therapeutic target. Additionally the involvement of the MET protein stands out as a specific player in familial cases of PRCC contributing to an inherited predisposition to this type of cancer.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human Papillary renal cell carcinoma protein (ab159181)
ab159181 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com