Recombinant Human Papillomavirus 16 (E7) protein (His tag) is a Human papillomavirus type 16 Full Length protein, in the 1 to 98 aa range with >90% purity and suitable for SDS-PAGE and mass spectrometry. The predicted molecular weight of ab237790 protein is 15 kDa.
- Save time and ensure accurate results - use our recombinant Human Papillomavirus 16 (HPV16 E7) protein as a control
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M H G D T P T L H E Y M L D L Q P E T T D L Y C Y E Q L N D S S E E E D E I D G P A G Q A E P D R A H Y N I V T F C C K C D S T L R L C V Q S T H V D I R T L E D L L M G T L G I V C P I C S Q K P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
Additional Targets
Human Papillomavirus 16 (E7)
Alternative names
Protein E7, E7
Recommended products
Recombinant Human Papillomavirus 16 (E7) protein (His tag) is a Human papillomavirus type 16 Full Length protein, in the 1 to 98 aa range with >90% purity and suitable for SDS-PAGE and mass spectrometry. The predicted molecular weight of ab237790 protein is 15 kDa.
- Save time and ensure accurate results - use our recombinant Human Papillomavirus 16 (HPV16 E7) protein as a control
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- P03129-1
- Animal free
- No
- Species
- Human papillomavirus type 16
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- M H G D T P T L H E Y M L D L Q P E T T D L Y C Y E Q L N D S S E E E D E I D G P A G Q A E P D R A H Y N I V T F C C K C D S T L R L C V Q S T H V D I R T L E D L L M G T L G I V C P I C S Q K P
- Accession
- P03129
- Protein length
- Full Length
- Predicted molecular weight
- 15 kDa
- Amino acids
- 1 to 98
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
- Sequence similarities
Belongs to the papillomaviridae E7 protein family.
- Post-translational modifications
Highly phosphorylated.
- Subcellular localisation
- Host nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Product promise
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3 product images
SDS-PAGE - Recombinant Human Papillomavirus 16 (E7) protein (His tag) (ab237790)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab237790.
Mass Spectrometry - Recombinant Human Papillomavirus 16 (E7) protein (His tag) (ab237790)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab237790 could indicate that this peptide derived from E.coli-expressed Human Papillomavirus 16 (E7).
Mass Spectrometry - Recombinant Human Papillomavirus 16 (E7) protein (His tag) (ab237790)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab237790 could indicate that this peptide derived from E.coli-expressed Human Papillomavirus 16 (E7).
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