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AB183171

Recombinant Human Paralemmin-1 protein

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Recombinant Human Paralemmin-1 protein is a Human Full Length protein, in the 1 to 387 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

KIAA0270, PALM, Paralemmin-1, Paralemmin

1 Images
SDS-PAGE - Recombinant Human Paralemmin-1 protein (AB183171)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Paralemmin-1 protein (AB183171)

15% SDS-PAGE analysis of ab183171 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

O75781

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Paralemmin
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTPSSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRAPAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPLRTVDGSPMMKAAMYSVEITVEKDKVTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDGTAENGIHPLSSSEVDELIHKADEVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQPGQEPPVTMIFMGYQNVEDEAETKKVLGLQDTITAELVVIEDAAEPKEPAPPNGSAAEPPTEAASREENQAGPEATTSDPQDLDMKKHRCKCCSIM","proteinLength":"Full Length","predictedMolecularWeight":"69 kDa","actualMolecularWeight":null,"aminoAcidEnd":387,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75781","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Paralemmin-1 also known as PALM is a lipid-anchored protein linked to the plasma membrane and involved in cellular processes that regulate cell shape and plasticity. It has a molecular weight of approximately 42 kDa. This protein expresses mainly in the brain particularly in regions like the hippocampus suggesting its significant role in neural cell function. Some data also note its presence in other tissues like the kidney and testis but at much lower levels compared to neural tissue.
Biological function summary

Paralemmin-1 plays a role in cellular membrane dynamics and structure. It assists in the stabilization of filopodia and participates in the regulation of neurite outgrowth both critical in neural development and maintenance. Although not a well-defined complex member Paralemmin-1 interacts with other proteins involved in cytoskeletal reorganization highlighting its importance in cellular morphology.

Pathways

Some studies point out that Paralemmin-1 associates with signaling cascades controlling actin cytoskeleton rearrangement particularly the Rho GTPase pathway. This protein interfaces with small GTPases like Cdc42 or Rac1 that drive changes in cell shape and motility directly linking it to the regulation of actin dynamics. Such interactions highlight its involvement in pathways integral to cell structure and signaling.

Deficits in Paralemmin-1 function have correlations with neurological disorders such as autism spectrum disorders (ASD) and intellectual disability. Pathologies like these show altered neuronal connectivity and synaptic plasticity areas where Paralemmin-1's role becomes important through its interaction with proteins like synaptic adhesion molecules. These associations point to Paralemmin-1 as a potential target for understanding and possibly modifying the progression of these neurological conditions.
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Specifications

Form

Liquid

Additional notes

ab183171 was purified using conventional chromatography techniques.

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General info

Function

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.

Sequence similarities

Belongs to the paralemmin family.

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Product protocols

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Target data

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.
See full target information PALM
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