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AB134616

Recombinant Human PARVA protein

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Recombinant Human PARVA protein is a Human Full Length protein, in the 1 to 372 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

MXRA2, PARVA, Alpha-parvin, Actopaxin, CH-ILKBP, Calponin-like integrin-linked kinase-binding protein, Matrix-remodeling-associated protein 2

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SDS-PAGE - Recombinant Human PARVA protein (AB134616)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PARVA protein (AB134616)

15% SDS-PAGE analysis of 3 µg ab134616.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9NVD7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Parvin alpha
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSELQEEGMNAINLPLSPIPFELDPEDTMLEENEVRTMVDPNSRSDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKSLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE","proteinLength":"Full Length","predictedMolecularWeight":"44.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":372,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NVD7","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein PARVA also known as α-parvin is a 42 kDa protein expressed in various tissues including muscle and endothelial cells. PARVA acts mechanically as an adaptor protein playing an important role within focal adhesions. It interacts with structural and signaling molecules integrating signals from the extracellular matrix. Through such interactions it contributes to cellular adhesion and migration processes.
Biological function summary

PARVA plays a role in cytoskeletal organization and cell shape regulation. As part of the integrin-linked kinase (ILK) complex it connects integrins at the cell surface with actin filaments in the cytoskeleton. This complex formation influences intracellular signaling pathways allowing cells to respond to mechanical stress and environmental signals. The dynamic restructuring of the actin cytoskeleton through PARVA is essential for cellular motility and morphogenesis.

Pathways

PARVA is an integral component of the PI3K-Akt signaling pathway and is also involved in the RhoA/ROCK pathway. Within these pathways it collaborates with proteins like integrin-linked kinase (ILK) and PINCH to mediate cell survival proliferation and migration. These pathways are essential for various cellular responses positioning PARVA as a significant element in controlling cellular behavior in response to external stimuli.

Research reveals PARVA's involvement in cancer progression and cardiovascular diseases. In cancer aberrant PARVA function or expression can alter cell adhesion and motility contributing to metastasis. Collaborating proteins like ILK and PINCH become deregulated influencing pathways associated with tumor growth. In cardiovascular disorders PARVA's role in endothelial cell function impacts vascular integrity where its dysregulation can lead to conditions such as atherosclerosis.
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Specifications

Form

Liquid

Additional notes

ab134616 is purified using conventional chromatography techniques.

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General info

Function

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed : 30367047).

Sequence similarities

Belongs to the parvin family.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed : 30367047).
See full target information PARVA
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