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AB171496

Recombinant Human PAX9 protein (denatured) (His tag N-Terminus)

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Recombinant Human PAX9 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 341 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

Paired box protein Pax-9, PAX9

1 Images
SDS-PAGE - Recombinant Human PAX9 protein (denatured) (His tag N-Terminus) (AB171496)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human PAX9 protein (denatured) (His tag N-Terminus) (AB171496)

15% SDS-PAGE analysis of ab171496 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P55771

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEPAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLAQQGHYDSYKQHQPTPQPALPYNHIYSYPSPITAAAAKVPTPPGVPAIPGSVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEEWSSLGRNNFPAAAPHAVNGLEKGALEQEAKYGQAPNGLPAVGSFVSASSMAPYPTPAQVSPYMTYSAAPSGYVAGHGWQHAGGTSLSPHNCDIPASLAFKGMQAAREGSHSVTASAL","proteinLength":"Full Length","predictedMolecularWeight":"38.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":341,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P55771","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PAX9 also known as paired box gene 9 is a transcription factor with a molecular mass of approximately 37 kDa. It belongs to the PAX family of proteins characterized by the presence of a paired box domain. Mechanically PAX9 plays a role in DNA binding and transcriptional regulation of target genes. It is expressed in developing teeth craniofacial regions limbs and parts of the neural crest. This expression pattern highlights PAX9’s involvement in early developmental processes.
Biological function summary

PAX9 contributes significantly to developmental patterning and organogenesis. It functions as a part of a transcription factor complex that coordinates the gene networks necessary for these processes. PAX9 interacts with other PAX family members and developmental regulators mediating the formation of structures such as teeth and skeletal elements. PAX9’s role in these processes ensures proper structural differentiation and morphogenesis during development.

Pathways

PAX9 plays an important role in the tooth development pathway and the Wnt signaling pathway. During tooth development it interacts with proteins like MSX1 and BMP4 guiding tooth patterning and morphogenesis. In the Wnt pathway PAX9 influences cell signaling pivotal for cell fate determination and embryonic development where it cooperates with Wnt proteins to modulate pathway-specific gene expression.

Mutations or dysregulation of PAX9 have been associated with conditions such as tooth agenesis and oral clefts. Tooth agenesis which involves missing teeth arises from disruptions in PAX9’s functionality during tooth development often involving MSX1 as well. Oral clefts such as cleft lip and palate also involve PAX9 interactions during craniofacial development. These associations emphasize PAX9's critical role in maintaining normal developmental functions and its impact on congenital anomalies.
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Specifications

Form

Liquid

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General info

Function

Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
See full target information PAX9
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Primary Antibodies

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