Recombinant Human PBX2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

PBX2 acts as a transcription factor altering gene expression by interacting with other nuclear proteins. It forms complexes often partnering with Hox proteins and Meis1 to regulate developmental and differentiation processes. This binding to other proteins enables PBX2 to control various cellular functions including cell proliferation and apoptosis which are important for normal development. The PBX2 gene also influences hematopoiesis contributing to the formation of blood cells and maintaining their functions.

Pathways

PBX2 is involved in several important pathways associated with development and cell fate determination. PBX2 plays a role in the Wnt signaling pathway which is important for cell communication proliferation and differentiation. It partners with other transcription factors like Hox proteins and Meis1 which modulate pathways leading to embryonic development and organogenesis. These interactions illustrate the sustained importance of PBX2 in providing transcriptional regulation across different cells and tissues.