Recombinant Human PBX2 protein is a Human Full Length protein, in the 1 to 430 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M D E R L L G P P P P G G G R G G L G L V S G E P G G P G E P P G G G D P G G G S G G V P G G R G K Q D I G D I L Q Q I M T I T D Q S L D E A Q A K K H A L N C H R M K P A L F S V L C E I K E K T G L S I R S S Q E E E P V D P Q L M R L D N M L L A E G V A G P E K G G G S A A A A A A A A A S G G G V S P D N S I E H S D Y R S K L A Q I R H I Y H S E L E K Y E Q A C N E F T T H V M N L L R E Q S R T R P V A P K E M E R M V S I I H R K F S A I Q M Q L K Q S T C E A V M I L R S R F L D A R R K R R N F S K Q A T E V L N E Y F Y S H L S N P Y P S E E A K E E L A K K C G I T V S Q V S N W F G N K R I R Y K K N I G K F Q E E A N I Y A V K T A V S V T Q G G H S R T S S P T P P S S A G S G G S F N L S G S G D M F L G M P G L N G D S Y S A S Q V E S L R H S M G P G G Y G D N L G G G Q M Y S P R E M R A N G S W Q E A V T P S S V T S P T E G P G S V H S D T S N
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.
Alternative names
G17, PBX2, Pre-B-cell leukemia transcription factor 2, Homeobox protein PBX2, Protein G17
Recommended products
Recombinant Human PBX2 protein is a Human Full Length protein, in the 1 to 430 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- P40425-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M D E R L L G P P P P G G G R G G L G L V S G E P G G P G E P P G G G D P G G G S G G V P G G R G K Q D I G D I L Q Q I M T I T D Q S L D E A Q A K K H A L N C H R M K P A L F S V L C E I K E K T G L S I R S S Q E E E P V D P Q L M R L D N M L L A E G V A G P E K G G G S A A A A A A A A A S G G G V S P D N S I E H S D Y R S K L A Q I R H I Y H S E L E K Y E Q A C N E F T T H V M N L L R E Q S R T R P V A P K E M E R M V S I I H R K F S A I Q M Q L K Q S T C E A V M I L R S R F L D A R R K R R N F S K Q A T E V L N E Y F Y S H L S N P Y P S E E A K E E L A K K C G I T V S Q V S N W F G N K R I R Y K K N I G K F Q E E A N I Y A V K T A V S V T Q G G H S R T S S P T P P S S A G S G G S F N L S G S G D M F L G M P G L N G D S Y S A S Q V E S L R H S M G P G G Y G D N L G G G Q M Y S P R E M R A N G S W Q E A V T P S S V T S P T E G P G S V H S D T S N
- Accession
- P40425
- Protein length
- Full Length
- Amino acids
- 1 to 430
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.
- Sequence similarities
Belongs to the TALE/PBX homeobox family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PBX2 also known as Pre-B-cell leukemia homeobox 2 is a homeodomain-containing transcription factor with a mass of approximately 38 kDa. It plays a role in regulating gene expression by binding to specific DNA sequences. PBX2 is expressed in various tissues including the bone marrow liver and gastrointestinal tract. This protein functions as part of the PBX family which includes other transcription factors like PBX1 and PBX3 known to participate in cellular processes that guide development and differentiation.
- Biological function summary
PBX2 acts as a transcription factor altering gene expression by interacting with other nuclear proteins. It forms complexes often partnering with Hox proteins and Meis1 to regulate developmental and differentiation processes. This binding to other proteins enables PBX2 to control various cellular functions including cell proliferation and apoptosis which are important for normal development. The PBX2 gene also influences hematopoiesis contributing to the formation of blood cells and maintaining their functions.
- Pathways
PBX2 is involved in several important pathways associated with development and cell fate determination. PBX2 plays a role in the Wnt signaling pathway which is important for cell communication proliferation and differentiation. It partners with other transcription factors like Hox proteins and Meis1 which modulate pathways leading to embryonic development and organogenesis. These interactions illustrate the sustained importance of PBX2 in providing transcriptional regulation across different cells and tissues.
- Associated diseases and disorders
PBX2 has associations with specific cancers including leukemia and breast cancer. Its interaction with Hox and Meis1 proteins is significant in the context of leukemia where the misregulation of these factors contributes to the disorder's pathogenesis. Additionally alterations in the regulation of PBX2 genetic activity may influence breast cancer progression by affecting pathways related to cell growth and survival. Understanding these interactions helps in developing targeted therapies for these diseases.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human PBX2 protein (ab159055)
ab159055 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com