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AB163332

Recombinant Human PCDHAC2 protein (GST tag N-Terminus)

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Recombinant Human PCDHAC2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 884 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Protocadherin alpha-C2, PCDH-alpha-C2, PCDHAC2

1 Images
SDS-PAGE - Recombinant Human PCDHAC2 protein (GST tag N-Terminus) (AB163332)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PCDHAC2 protein (GST tag N-Terminus) (AB163332)

ab163332 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9Y5I4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MEQAGTRPAATEHPRLRRPMPWLLLLPLLLLLLLLLPGPAASQLRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVDRVSKILPDTQRHVKSPRTYSEITLYLIIALSTVSFIFLLTIIILSIIKCYRYTAYGTACCGGFCGVRERSPAELYKQANNNIDARIPHGLKVQPHFIEVRGNGSLTKTYCYKACLTAGSGSDTFMFYNTGAQTGPGPSGAQAAVTDSRNLTGQSGQNAGNLIILKNEAVSQNEVRQWSGGLLQTHAFVTHPPISCDLALLSH","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":884,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9Y5I4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCDHAC2 also known as protocadherin alpha C2 is part of the protocadherin alpha subfamily. This protein has a molecular mass of approximately 105 kDa. It localizes to the cell membrane prominently expressed in neural tissues. PCDHAC2 functions in cell-cell adhesion mediated largely through calcium-binding motifs in its extracellular domain. These interactions contribute to cellular communication and signal transduction essential for the nervous system development.
Biological function summary

Protocadherins like PCDHAC2 play pivotal roles in the neural architecture by mediating homophilic cell adhesion properties. PCDHAC2 does not function as a solitary entity; it forms part of multimeric cadherin complexes at cell junctions. Its ability to mediate specific cell-cell interactions enhances neural circuit organization and synaptic specificity. The precise patterning of these interactions contributes to the establishment of proper brain architecture and connectivity.

Pathways

PCDHAC2 integration involves the calcium-dependent cell adhesion pathway and the Wnt signaling pathway. These pathways are critical for embryonic development and neural differentiation. In these pathways the protein interacts with other cadherins and catenins providing stability and signaling functions. Its actions might regulate cytoskeletal dynamics influencing the neural network's architecture indirectly by modulating the expression of cytoplasmic proteins linked to cellular adhesion and signaling.

Aberrant PCDHAC2 expression or function connects to neurological disorders such as autism spectrum disorder and schizophrenia. These conditions may involve disruptions in neural connectivity and synaptic function. PCDHAC2-related dysfunctions can affect interactions with proteins like beta-catenin which are significant in signal transduction and synaptic structure. Understanding these associations may provide insights into the molecular pathology underpinning these disorders.
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Specifications

Form

Liquid

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General info

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

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Product protocols

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Target data

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
See full target information PCDHAC2
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