Recombinant Human PCDHB4 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCDHB4 also known as Protocadherin beta 4 is a neural adhesion protein involved in cell-cell communication. It is part of the protocadherin beta gene cluster and contains a single-exonal structure unique to this family. The protein has a mass of approximately 93 kDa. It is prominently expressed in the brain playing a role in the neuronal networks' formation and maintenance. PCDHB4 has similar structures to other protocadherins suggesting conserved functionalities within this protein family.

Biological function summary

PCDHB4 participates in the formation of neuronal synapses essential for effective neural signaling. It is not only a standalone protein but also a part of larger adhesive complexes that enable stable cell-cell interactions. By facilitating contact between neurons PCDHB4 influences synaptic specificity and neurite development key processes within the complex circuitry of the nervous system. These interactions are necessary for the organization of neural tissue and ensuring proper neural function.

Pathways

PCDHB4 plays a role in the cadherin signaling pathway a critical pathway related to cell-cell adhesion and communication. This pathway integrates various signals that lead to cellular responses affecting neural circuit assembly and synaptic plasticity. PCDHB4 shares functional interactions with alpha- and gamma-protocadherins which may also contribute to its involvement in the calcium-dependent cell adhesion pathway. Such interactions facilitate the regulation of diverse neural processes which are essential for maintaining brain structure and function.

PCDHB4 has associations with neurodevelopmental disorders including autism spectrum disorders. Mutations or altered expression of PCDHB4 might impact neural connectivity and synaptic function contributing to these conditions. It is connected to the broader family of protocadherins such as PCDHGA11 which have also shown associations with neural development disorders. Understanding the precise roles of PCDHB4 in these disorders may offer insights into potential therapeutic targets for improving treatment strategies.