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AB163309

Recombinant Human PCDHGB2 protein

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Recombinant Human PCDHGB2 protein is a Human Full Length protein, in the 1 to 811 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Protocadherin gamma-B2, PCDH-gamma-B2, PCDHGB2

1 Images
SDS-PAGE - Recombinant Human PCDHGB2 protein (AB163309)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PCDHGB2 protein (AB163309)

ab163309 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9Y5G2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MKASSGRCGLVRWLQVLLPFLLSLFPGALPVQIRYSIPEELAKNSVVGNLAKDLGLSVRDLPARKLRVSAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGDLAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILKSSSKNYYKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEVLPDLSDRREPSDPQAKLQFYLVVALALISVLFFLAVILAISLRLRLSSRSDAWDCFQPGLSSKPGPGVLPNYSEGTLPYSYNLCVASQSAKTEFNFLNITPELVPAQDLVCDNASWEQNTNHGAAGVPFASDTILKVSFN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":811,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9Y5G2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCDHGB2 also known as protocadherin gamma-B2 is a member of the protocadherin gamma gene cluster. This protein has a mass of approximately 104 kDa and is typically expressed in the brain where it plays a role in cell adhesion and communication. It functions mechanically as a component of the cell-surface adhesion molecules which are responsible for specific recognition and connections between neurons.
Biological function summary

Protocadherin gamma-B2 is involved in the formation and maintenance of neural networks. It contributes to the stabilization of synaptic structures by facilitating homophilic binding among neuron membranes. PCDHGB2 is part of a large protocadherin family known for its role in brain development and neuronal diversity. The interactions within this complex contribute to the specificity of neural connections necessary for proper brain function.

Pathways

The protein plays a role in neuron connectivity and signal transmission processes. PCDHGB2 is involved in the cellular adhesion pathway which directly influences synaptic signaling. It associates with other protocadherins and possibly interacts with cadherin-related proteins impacting signal transduction necessary for organizing neuronal circuitries within the brain.

PCDHGB2 is associated with certain neurological conditions although research is still ongoing. Alterations in its expression or function have been linked with neurodevelopmental disorders such as autism spectrum disorders (ASD). This can involve a dysregulation of synaptic signaling in the brain. Other proteins such as members of the cadherin family may also link to these pathologies highlighting the importance of correct protocadherin expression for maintaining neural health.
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Specifications

Form

Liquid

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General info

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

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Product protocols

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Target data

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
See full target information PCDHGB2
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