Recombinant Human PCDHGB4 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Protocadherin gamma-B4 (PCDHGB4) is a type of cell-adhesion molecule belonging to the protocadherin gamma gene cluster often called PCDH-GAMMA-B4. This protein is known to weigh approximately 102.5 kDa. PCDHGB4 is expressed in the brain and spinal cord with a special expression in the central nervous system. It plays an important role in maintaining cell-cell communication mediating cell adhesion within the neural tissues.

Biological function summary

PCDHGB4 participates in the modulation of neuronal connections and synaptic functions. It operates as part of a large and diverse family of cadherin-related proteins impacting various signal transduction processes. PCDHGB4 supports the formation of specific neuronal networks and influences signal specificity which helps in brain development and neuronal pathway establishment. Many members of the protocadherin family collaborate to form functional complexes that contribute to neural diversity.

Pathways

Protocadherin gamma-B4 functions within the neuronal adhesion pathway and interacts with cadherin-related proteins. It is involved in the pathways responsible for the development and maintenance of synaptic junctions often working closely with similar proteins like PCDHGB5 and classical cadherins. These pathways are fundamental for nervous system development and proper synaptic functioning.

Disruptions or mutations in PCDHGB4 have potential links to neurological disorders such as autism spectrum disorders (ASD) and epilepsy. These conditions might involve problems in neuronal connections and signaling where PCDHGB4 may play a significant role. Research indicates interactions between PCDHGB4 and other synaptic proteins like neuroligins which could relate to these neurological conditions. Understanding these connections can open avenues for targeted therapies in related pathologies.