Recombinant Human PCDHGC4 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCDHGC4 also known as Protocadherin gamma-C4 is a member of the protocadherin gamma gene cluster and it plays a role in cell-cell adhesion processes. This protein is part of the cadherin superfamily and has a predicted molecular mass of approximately 120 kDa. PCDHGC4 is widely expressed in the brain suggesting its role in neural activities. It is predominantly found in synapses where it contributes to the maintenance and organization of synaptic structures.

Biological function summary

PCDHGC4 is involved in the regulation of cell adhesion critical for the establishment and remodeling of connections between neurons. It forms part of a complex with other protocadherins to influence cell signaling pathways that regulate neural patterning and synaptic specificity. PCDHGC4 helps to maintain neuronal connectivity and may have implications in neural plasticity due to its interactions with various molecular components at the synapses.

Pathways

PCDHGC4 is implicated in the classical cadherin-signaling pathway and is also connected to the Wnt signaling pathway. In these pathways PCDHGC4 interacts with other protocadherin family members and cadherin proteins influencing signal transduction events critical for neuron interactions and networking. The Wnt signaling pathway which PCDHGC4 is aligned with significantly relates to cellular processes like proliferation and migration within the nervous system.

PCDHGC4 has been studied for its association with neurodevelopmental disorders including autism spectrum disorder where deviations in synaptic connectivity are evident. Altered expression of PCDHGC4 has been observed in certain forms of epilepsy suggesting its role in maintaining synaptic balance and prevention of excitatory-inhibitory imbalance. These associations indicate that PCDHGC4 and its interactions with proteins such as other protocadherins might be integral to understanding and potentially addressing these neural disorders.