Recombinant Human PCMTD1 protein - BSA and Azide free (His tag N-Terminus)
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Recombinant Human PCMTD1 protein - BSA and Azide free (His tag N-Terminus) is a Human Fragment protein, in the 1 to 220 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.
View Alternative Names
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1, PCMTD1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human PCMTD1 protein - BSA and Azide free (His tag N-Terminus) (AB174387)
SDS-PAGE analysis PCMTD1 using 3 μg of ab174387 on a 15% gel.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The PCMTD1 enzyme prevents the accumulation of damaged proteins which could otherwise disrupt cellular functions. It forms part of a greater protein repair mechanism working alongside other correction processes to maintain protein integrity. Specifically PCMTD1 contributes to maintaining protein stability and functionality preventing erroneous protein folding that might disrupt normal cellular operations.
Pathways
Researchers place PCMTD1 within the protein repair and degradation pathways linking it to cellular proteostasis. It interacts with other enzymatic components involved in protein turnover such as the ubiquitin-proteasome system. This collaboration ensures damaged proteins are repaired or removed to uphold cell homeostasis. PCMTD1's role in these pathways is important for maintaining the balance between protein synthesis and degradation which is necessary for normal cellular functions.
Specifications
Form
Liquid
Additional notes
ab174387 is purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20 mM Tris pH 7.5, 2 mM EDTA.
General info
Function
Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed : 35486881). Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity (PubMed : 35486881). May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein (PubMed : 35486881).
Sequence similarities
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
Target data
Complementary Products
Product promise
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