Recombinant Human PCP4L1 protein - BSA and Azide free is a Human Full Length protein, in the 1 to 68 aa range, expressed in Escherichia coli, with >85% purity and suitable for MS, SDS-PAGE.
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Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- MS, SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M S E L N T K T S P A T N Q A A G Q E E K G K A G N V K K A E E E E E I D I D L T A P E T E K A A L A I Q G K F R R F Q K R K K D P S S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes Use at 3 μg/lane |
Target data
Alternative names
IQM1, PCP4L1, Purkinje cell protein 4-like protein 1, PCP4-like protein 1
Recommended products
Recombinant Human PCP4L1 protein - BSA and Azide free is a Human Full Length protein, in the 1 to 68 aa range, expressed in Escherichia coli, with >85% purity and suitable for MS, SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- MS, SDS-PAGE
- Biologically active
- No
- Accession
- A6NKN8-1
- Animal free
- No
- Carrier free
- Yes
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris-HCl buffer
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M S E L N T K T S P A T N Q A A G Q E E K G K A G N V K K A E E E E E I D I D L T A P E T E K A A L A I Q G K F R R F Q K R K K D P S S
- Accession
- A6NKN8
- Protein length
- Full Length
- Predicted molecular weight
- 9.9 kDa
- Amino acids
- 1 to 68
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab174388 is purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20 mM Tris pH 7.5, 2 mM EDTA.
General info
- Sequence similarities
Belongs to the PCP4 family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PCP4L1 also known as Purkinje cell protein 4-like protein 1 is a small protein with a molecular mass of around 7 kDa. This protein belongs to the calmodulin-binding protein family and is mostly expressed in neuronal tissues including areas of the brain. PCP4L1 has a role in modulating calcium signaling by interacting with calmodulin an important calcium-binding messenger protein emphasizing its involvement in calcium-related cellular processes.
- Biological function summary
PCP4L1 interacts with calmodulin affecting cellular processes dependent on calcium signaling. Calmodulin binding is important for modulation of signal transduction pathways helping to manage calcium influx and neuronal excitability. PCP4L1 may also influence cytoskeletal dynamics due to its interaction with other neuronal proteins. Its particular expression in the brain hints at a specialized function in neurophysiological activities although it doesn't form a larger known complex.
- Pathways
One can observe that PCP4L1 integration into calcium signaling cascades suggests its role in neuronal pathways such as synaptic plasticity. This calcium modulation impacts neurotransmission efficiency and synaptic connections. PCP4L1 might have associations with proteins like CaMKII involved in calcium-mediated signaling. The regulation and repercussions of calcium homeostasis are important within these pathways.
- Associated diseases and disorders
Disruptions in PCP4L1 levels or function may link to neurological conditions such as cerebral ataxia or epilepsy. Abnormal calcium signaling in neurons managed poorly due to inadequate PCP4L1 activity factors into these conditions. Furthermore interactions with alpha-synuclein could connect PCP4L1 to neurodegenerative disorders like Parkinson’s disease representing core pathways implicating synaptic and neuronal health.
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1 product image
SDS-PAGE - Recombinant Human PCP4L1 protein - BSA and Azide free (ab174388)
SDS-PAGE analysis PCP4L1 using 3 μg of ab174388 on a 15% gel.
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Product protocols
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