Recombinant Human PCTAIRE1 protein is a Human Fragment protein, in the 158 to 496 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S G F G K L E T Y I K L D K L G E G T Y A T V Y K G K S K L T D N L V A L K E I R L E H E E G A P C T A I R E V S L L K D L K H A N I V T L H D I I H T E K S L T L V F E Y L D K D L K Q Y L D D C G N I I N M H N V K L F L F Q L L R G L A Y C H R Q K V L H R D L K P Q N L L I N E R G E L K L A D F G L A R A K S I P T K T Y S N E V V T L W Y R P P D I L L G S T D Y S T Q I D M W G V G C I F Y E M A T G R P L F P G S T V E E Q L H F I F R I L G T P T E E T W P G I L S N E E F K T Y N Y P K Y R A E A L L S H A P R L D S D G A D L L T K L L Q F E G R N R I S A E D A M K H P F F L S L G E R I H K L P D T T S I F A L K E I Q L Q K E A S L R S S S M P D S G R P A F R V V D T E F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).
Alternative names
Cyclin-dependent kinase 16, Cell division protein kinase 16, PCTAIRE-motif protein kinase 1, Serine/threonine-protein kinase PCTAIRE-1, PCTK1, PCTAIRE1, CDK16
Recommended products
Recombinant Human PCTAIRE1 protein is a Human Fragment protein, in the 158 to 496 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Alternative names
Cyclin-dependent kinase 16, Cell division protein kinase 16, PCTAIRE-motif protein kinase 1, Serine/threonine-protein kinase PCTAIRE-1, PCTK1, PCTAIRE1, CDK16
Key facts
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
- Accession
- Q00536-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris-HCl buffer
Sequence info
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S G F G K L E T Y I K L D K L G E G T Y A T V Y K G K S K L T D N L V A L K E I R L E H E E G A P C T A I R E V S L L K D L K H A N I V T L H D I I H T E K S L T L V F E Y L D K D L K Q Y L D D C G N I I N M H N V K L F L F Q L L R G L A Y C H R Q K V L H R D L K P Q N L L I N E R G E L K L A D F G L A R A K S I P T K T Y S N E V V T L W Y R P P D I L L G S T D Y S T Q I D M W G V G C I F Y E M A T G R P L F P G S T V E E Q L H F I F R I L G T P T E E T W P G I L S N E E F K T Y N Y P K Y R A E A L L S H A P R L D S D G A D L L T K L L Q F E G R N R I S A E D A M K H P F F L S L G E R I H K L P D T T S I F A L K E I Q L Q K E A S L R S S S M P D S G R P A F R V V D T E F
- Accession
- Protein length
Fragment
- Predicted molecular weight
41.1 kDa
- Amino acids
158 to 496
- Nature
Recombinant
- Tags
His tag N-Terminus
Specifications
- Form
Liquid
- Additional notes
Purified using conventional chromatography techniques.
General info
- Function
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).
- Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Post-translational modifications
Phosphorylation at Ser-153 inhibits kinase activity.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PCTAIRE1 also known as Cyclin-dependent kinase 16 (CDK16) plays a significant mechanical role as a serine/threonine kinase. This protein with a molecular weight of approximately 45 kDa participates in various intracellular processes. It shows expression in multiple tissues including prominently in the brain and testis. PCTAIRE1 regulates cellular events by phosphorylating target proteins thereby influencing their function.
- Biological function summary
PCTAIRE1 influences certain cellular functions such as signal transduction and neuron differentiation. It exists as part of complexes that include cyclins which modulate its kinase activity. In neurons PCTAIRE1 contributes to processes like neurite outgrowth and synaptic function. Research indicates a role in the transport of synaptic vesicles hinting at its involvement in neurotransmitter release and communication between neurons.
- Pathways
PCTAIRE1 serves as a component of pathways such as the Wnt signaling pathway and the cell cycle. Its function aligns with several other proteins including CDK16 in modulating processes like cell proliferation and neural development. PCTAIRE1 interacts closely with proteins like Cyclin Y which help guide its role in these pathways ensuring proper progression of related biological events.
- Associated diseases and disorders
PCTAIRE1 has associations with neurological disorders and certain cancers. Abnormal expression or activity of PCTAIRE1 may relate to conditions like schizophrenia or glioblastoma. The protein's interaction with Cyclin Y is key in the context of cancer where dysregulation of these interactions can contribute to tumor progression. Alterations in PCTAIRE1 function and its pathways highlight its potential as a target for therapeutic strategies in these diseases.
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1 product image
SDS-PAGE - Recombinant Human PCTAIRE1 protein (ab176035)
15% SDS-PAGE analysis of ab176035 (3μg).
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