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AB190412

Recombinant Human PCTAIRE2 protein

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Recombinant Human PCTAIRE2 protein is a Human Full Length protein, in the 1 to 523 aa range, expressed in Baculovirus infected Sf9 cells, with >75%, suitable for WB.

View Alternative Names

PCTAIRE2, PCTK2, CDK17, Cyclin-dependent kinase 17, Cell division protein kinase 17, PCTAIRE-motif protein kinase 2, Serine/threonine-protein kinase PCTAIRE-2

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SDS-PAGE - Recombinant Human PCTAIRE2 protein (AB190412)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PCTAIRE2 protein (AB190412)

SDS-PAGE analysis of ab190412

Key facts

Purity

>75% Densitometry

Affinity purified.

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

WB

applications

Biologically active

No

Accession

Q00537

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF","proteinLength":"Full Length","predictedMolecularWeight":"88 kDa","actualMolecularWeight":null,"aminoAcidEnd":523,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q00537","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCTAIRE2 also known as cyclin-dependent kinase 17 (CDK17) belongs to the large kinase family specifically involved in cell cycle regulation. It has a molecular mass of approximately 57 kDa and is mainly expressed in the brain and testis tissues. Like other members of the CDK family PCTAIRE2's activity is regulated by the binding of cyclins but it displays distinct substrate specificities. This protein structure includes a conserved kinase domain that suggests its role in phosphorylation and signal transduction processes.
Biological function summary

PCTAIRE2 functions in the modulation of neurodevelopmental processes and perhaps in the regulation of signal transmission in neurons. It may form complexes with various regulatory subunits affecting neuronal differentiation and outgrowth specifically in the brain. The presence of PCTAIRE2 in testis tissue indicates its potential role in reproductive biology though this function remains less understood compared to its neurological activities.

Pathways

PCTAIRE2 participates actively in pathways linked to neuronal signaling and development. The phosphorylation activity of PCTAIRE2 intertwines with proteins such as cyclins enabling the progression and regulation of cellular cycles particularly within neuronal cells. Moreover PCTAIRE2 links to pathways that include synaptic signaling interacting with related kinases that impact neuron structure and function though specific relationships to direct pathway members remain under ongoing investigation.

Researchers associate PCTAIRE2 with neurodegenerative conditions like Alzheimer's disease given its significant role in the brain. Its dysregulation could affect neuronal signaling pathways potentially leading to cognitive deficits. Additionally abnormalities in PCTAIRE2 expression relate to disorders of the male reproductive system though the precise mechanisms require further elucidation. Its interaction with key proteins such as tau protein may uncover further insights about its role in disease pathology where tauopathy plays a part.
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General info

Function

May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

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Product protocols

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Target data

May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).
See full target information CDK17
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