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AB268840

Recombinant human PCTAIRE3 + Cyclin Y protein (Active)

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Recombinant human PCTAIRE3 + Cyclin Y protein (Active) is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with >70%, suitable for SDS-PAGE, FuncS.

View Alternative Names

PCTAIRE3, PCTK3, CDK18, Cyclin-dependent kinase 18, Cell division protein kinase 18, PCTAIRE-motif protein kinase 3, Serine/threonine-protein kinase PCTAIRE-3

2 Images
Functional Studies - Recombinant human PCTAIRE3 + Cyclin Y protein (Active) (AB268840)
  • FuncS

Supplier Data

Functional Studies - Recombinant human PCTAIRE3 + Cyclin Y protein (Active) (AB268840)

The specific activity of ab268840 was 46 nmol/min/mg in a kinase assay using MBP protein substrate.

SDS-PAGE - Recombinant human PCTAIRE3 + Cyclin Y protein (Active) (AB268840)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human PCTAIRE3 + Cyclin Y protein (Active) (AB268840)

SDS-PAGE analysis of ab268840.

Key facts

Purity

>70% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

Tag free

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

The specific activity of ab268840 was 46 nmol/min/mg in a kinase assay using MBP protein substrate.

Accession

Q07002

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q07002","tags":[{"tag":"GST","terminus":"N-Terminus"}]},{"sequence":"GNTTSCCVSSSPKLRRNAHSRLESYRPDTDLSREDTGCNLQHISDRENIDDLNMEFNPSDHPRASTIFLSKSQTDVREKRKSLFINHHPPGQIARKYSSCSTIFLDDSTVSQPNLKYTIKCVALAIYYHIKNRDPDGRMLLDIFDENLHPLSKSEVPPDYDKHNPEQKQIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNELERQFLELLQFNINVPSSVYAKYYFDLRSLAEANNLSFPLEPLSRERAHKLEAISRLCEDKYKDLRRSARKRSASADNLTLPRWSPAIIS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":341,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q8ND76","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCTAIRE3 also known as Cyclin Y is a member of the cyclin-dependent kinase (CDK) family. It weighs approximately 64 kDa and shows high expression in the testis and brain. PCTAIRE3 interacts with cyclin Y to exert its functions forming a cyclin-CDK complex. This interaction is important for full catalytic activity. PCTAIRE3 regulates phosphorylation a critical step in numerous cellular processes.
Biological function summary

The activity of PCTAIRE3 involves promotion of cell cycle progression and reorganization of actin in cells. The protein functions in conjunction with its cyclin partners to control these processes. As part of a complex with cyclin Y PCTAIRE3 facilitates the regulation of various stages of the cell cycle especially transitions through different phases. It plays a role in regulating cell structures contributing to the rearrangement of cytoskeletal components during cell division.

Pathways

PCTAIRE3 is closely associated with the regulation of the cell cycle and signal transduction pathways. It shows involvement in cell-cycle-related signaling cascades where it partners with proteins such as cyclin E and Cdk2. These interactions ensure proper cell cycle progression and response to growth signals. Through these pathways PCTAIRE3 contributes to maintaining the balance between cell proliferation and differentiation.

The dysregulation of PCTAIRE3 associates with certain cancers and neurodegenerative conditions. Altered expression of PCTAIRE3 has been observed in breast cancer suggesting its involvement in tumorigenesis. Additionally disruptions in pathways associated with PCTAIRE3 could link to neurodegenerative disorders with potential connections to proteins like tau which relate to these diseases. Understanding PCTAIRE3 functions in these contexts remains critical for exploring potential therapeutic approaches.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

May play a role in signal transduction cascades in terminally differentiated cells.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

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Product protocols

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Target data

May play a role in signal transduction cascades in terminally differentiated cells.
See full target information CDK18

Additional targets

CCNY
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