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AB179959

Recombinant Human PCTAIRE3 protein

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Recombinant Human PCTAIRE3 protein is a Human Full Length protein, in the 1 to 472 aa range, expressed in Baculovirus infected Sf9 cells, with >75%, suitable for SDS-PAGE, WB.

View Alternative Names

PCTAIRE3, PCTK3, CDK18, Cyclin-dependent kinase 18, Cell division protein kinase 18, PCTAIRE-motif protein kinase 3, Serine/threonine-protein kinase PCTAIRE-3

1 Images
SDS-PAGE - Recombinant Human PCTAIRE3 protein (AB179959)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PCTAIRE3 protein (AB179959)

SDS-PAGE analysis of ab179959.

Key facts

Purity

>75% Densitometry

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE

applications

Biologically active

No

Accession

Q07002

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF","proteinLength":"Full Length","predictedMolecularWeight":"76 kDa","actualMolecularWeight":null,"aminoAcidEnd":472,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q07002","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCTAIRE3 also known as cyclin-dependent kinase 18 (CDK18) is a serine/threonine protein kinase. It has a molecular mass of approximately 37 kDa. Typically this protein is found in high amounts in the testis brain and pancreas. PCTAIRE3 plays a role in cellular processes by acting as a regulatory kinase. It is involved in phosphorylating specific substrates which is important for its function.
Biological function summary

PCTAIRE3 contributes to cell cycle regulation and neuronal signaling. It is a part of the cyclin-dependent kinase (CDK) family which is responsible for controlling progression through the cell cycle. These kinases often form complexes with cyclins to perform their regulatory roles effectively. The protein's expression in neuronal tissues suggests a role in synaptic plasticity or neuronal development though exact mechanisms need further study.

Pathways

PCTAIRE3 participates in the cell cycle and signal transduction pathways. It interacts with other CDKs and cyclins to help coordinate the cell cycle particularly in the G2/M transition. PCTAIRE3's involvement with these pathways links it to proteins like cyclin B and CDK1. Additionally its presence in signal transduction pathways connects it to various molecular signals which influence cellular responses and decisions.

Mutations or dysregulation of PCTAIRE3 have been implicated in cancers and neurodevelopmental disorders. In cancer aberrant expression of CDKs can lead to uncontrolled cell proliferation. PCTAIRE3 has been associated with specific tumors where it may interact with proteins like p53 that are critical in controlling the cell cycle and tumor suppression. In neurodevelopmental disorders variations in PCTAIRE3 might influence synaptic signaling contributing to conditions such as schizophrenia though research on these connections remains ongoing.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

May play a role in signal transduction cascades in terminally differentiated cells.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

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Product protocols

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Target data

May play a role in signal transduction cascades in terminally differentiated cells.
See full target information CDK18
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Secondary Antibodies

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Primary Antibodies

AB154557

Anti-PCTAIRE3 antibody

Western blot - Anti-PCTAIRE3 antibody (AB154557)

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