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Recombinant Human PD-L1 (mutated D26A) protein (Tagged) (Biotin) is a Human Fragment protein, in the 19 to 239 aa range, expressed in HEK 293, with >=90% purity and suitable for SDS-PAGE.
Alternative names=Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, hPD-L1, B7 homolog 1, B7-H1, B7H1, CD274, PDCD1LG1, PDCD1L1, PDL1
- Purity
>=90% SDS-PAGE
- Expression system
HEK 293 cells
- Tags
Fc tag C-Terminus, Avi tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Conjugation
Biotin
Consider this alternative
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Images
Target data
Function
Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813417, PubMed:28813410). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity).
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Recombinant Human PD-L1 (mutated D26A) protein (Tagged) (Biotin) is a Human Fragment protein, in the 19 to 239 aa range, expressed in HEK 293, with >=90% purity and suitable for SDS-PAGE.
Alternative names=Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, hPD-L1, B7 homolog 1, B7-H1, B7H1, CD274, PDCD1LG1, PDCD1L1, PDL1
Key facts
- Purity
>=90% SDS-PAGE
- Expression system
HEK 293 cells
- Tags
Fc tag C-Terminus, Avi tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Conjugation
Biotin
- Predicted molecular weight
54 kDa
- Amino acids
19 to 239
- Accession
- Q9NZQ7-1
- Protein length
Fragment
- Animal free
No
- Nature
Recombinant
- Species
Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride
Specifications
- Form
Liquid
General info
- Function
Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).
- Sequence similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
- Post-translational modifications
Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
- Subcellular localisation
Early endosome membrane, Recycling endosome membrane
Storage
- Shipped at conditions
Dry Ice
- Appropriate long-term storage conditions
-80°C
- Storage information
Avoid freeze / thaw cycle
Notes
Enzymatically biotin-labeled using Avi-tag™ technology
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