Recombinant Human PDAP1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDAP1 also known as PDGFA-associated protein 1 is a protein with mass around 34 kDa. It associates with the A chain of platelet-derived growth factor (PDGFA) to modulate its activity. PDAP1 expression occurs widely across human tissues including high levels in the liver and pancreas which suggests its diverse roles within the body. Its interaction with growth factors like PDGFA points towards its involvement in cellular growth and development processes.

Biological function summary

The PDAP1 protein interacts with several cellular components to regulate cell proliferation and differentiation. Although not a component of a large protein complex its action still critically influences the PDGFA signaling pathway impacting cell growth. The modulation of PDGFA activity by PDAP1 plays an important role in controlling the positive effects of growth factors ensuring balanced cellular functions.

Pathways

PDAP1 features in the PDGF signaling pathway which is essential for various cellular processes like development and tissue repair. This signaling pathway influences physiological processes such as cell movement growth and survival through its interaction with PDGFA and other proteins such as PDGFR (platelet-derived growth factor receptor). These interactions highlight PDAP1's functional role in maintaining cellular and tissue homeostasis through well-regulated signaling cascades.

Altered PDAP1 activity links to certain pathological conditions including fibrosis and cancer. In fibrosis PDAP1’s relation to PDGFA influences excessive tissue scarring impacting organ function. In oncogenesis its modulation of growth factor signaling can lead to uncontrolled cell growth and tumor development. The association with key proteins like PDGFR in these conditions suggests that PDAP1 impacts disease progression and presents potential therapeutic targets for interventions.