Recombinant Human PDCL2 protein

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PDCL2 also known as Phosducin-like protein 2 belongs to the family of phosducin-like proteins that may act as a co-chaperone. It has a molecular weight of approximately 36 kDa. PDCL2 shows expression in various tissues with notable levels in the testis suggesting a role in reproductive tissues. This protein plays an essential mechanical function related to the regulation of G-protein signaling interacting with G protein beta-gamma subunits.

Biological function summary

PDCL2 possesses a significant role in cellular processes related to signal transduction. It does not function in isolation but rather becomes part of a larger protein complex that is critical for assisting the folding of G-protein subunits. This complex involvement affects various stages of G-protein coupled receptor signaling impacting cellular communication and response.

Pathways

PDCL2 integrates into the broader landscape of G-protein coupled receptor (GPCR) signaling mechanisms. This pathway is fundamental in transmitting extracellular signals into the cell influencing multiple cellular responses. The protein interacts with similar modules such as the chaperonin containing TCP1 which facilitates correct folding of the G-protein components. Furthermore PDCL2 has a relationship with other phosducin-like proteins that modulate GPCR signaling efficacy.

Associated diseases and disorders

Alterations in PDCL2 expression or function have tentative links to reproductive system anomalies and potential impacts on hormone regulation. The connection exists between PDCL2 and proteins like G-proteins which become implicated in hormonal imbalances. Additionally deviations in PDCL2 activity can contribute to conditions involving impaired signal transduction albeit more research is needed to fully elucidate the complete range of disorders associated with this molecule.