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AB123207

Recombinant Human PDCL3 protein (His tag N-Terminus)

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Recombinant Human PDCL3 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 239 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

PhLP2A, VIAF1, PDCL3, Phosducin-like protein 3, HTPHLP, PhPL3, Viral IAP-associated factor 1, VIAF-1

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SDS-PAGE - Recombinant Human PDCL3 protein (His tag N-Terminus) (AB123207)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human PDCL3 protein (His tag N-Terminus) (AB123207)

12% SDS-PAGE analysis of ab123207 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9H2J4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMQDPNADTEWNDILRKKGILPPKESLKELEEEAEEEQRILQQSVVKTYEDMTLEELEDHEDEFNEEDERAIEMYRRRRLAEWKATKLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCALINQHLSGLARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIGPLVFGGMNLTRDELEWKLSESGAIMTDLEENPKKPIEDVLLSSVRRSVLMKRDSDSEGD","proteinLength":"Full Length","predictedMolecularWeight":"30 kDa","actualMolecularWeight":null,"aminoAcidEnd":239,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H2J4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDCL3 also known as PhLP3 (Phosducin-like protein 3) is a protein that functions as a co-chaperone in cells. It weighs approximately 35 kDa and is expressed in various tissues including liver and lung. PDCL3 assists in the folding and stabilization of client proteins by forming complexes with other chaperone proteins particularly those involved in G protein signaling.
Biological function summary

PDCL3 plays an important role in regulating protein activity associated with GTP-binding proteins. It is part of a complex system that ensures the proper folding of G protein subunits. This activity helps maintain cellular signaling pathways contributing to cellular homeostasis. PDCL3's function as a modulator of protein folding makes it an able participant in the regulation of intracellular processes.

Pathways

PDCL3 takes part in key molecular pathways such as the G protein-coupled receptor (GPCR) signaling pathway. In this pathway PDCL3 interacts with proteins like Gβγ subunits to maintain correct protein conformation and functionality. This interaction allows for the effective transmission of signals from cell surface receptors to intracellular targets facilitating diverse cellular responses.

PDCL3's dysfunction can associate with conditions like neurodegenerative diseases and certain cancers. Its interaction with proteins such as G protein beta subunits highlights its potential role in disease progression. These associations suggest that alterations in PDCL3 expression or functionality can influence disease outcomes making it a target of interest for therapeutic interventions.
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Specifications

Form

Liquid

Additional notes

ab123207 is purified using conventional chromatography.

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General info

Function

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed : 23792958, PubMed : 26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed : 17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed : 15371430).

Sequence similarities

Belongs to the phosducin family.

Post-translational modifications

N-terminal methionine acetylation destabilizes the protein.

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Product protocols

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Target data

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed : 23792958, PubMed : 26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed : 17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed : 15371430).
See full target information PDCL3
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