Recombinant Human PDE12 protein
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Recombinant Human PDE12 protein is a Human Full Length protein, in the 1 to 609 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE.
View Alternative Names
2'-PDE, 2-PDE, Mitochondrial deadenylase, PDE12
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human PDE12 protein (AB107695)
SDS page analysis of ab107695
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
PDE12 primarily influences mitochondrial RNA processing. As part of this function it interacts with mt-tRNA to control the stability and maturation of mitochondrial RNA which is important for mitochondrial protein synthesis. It does not operate as part of a larger protein complex but rather exerts its effects through direct interaction with its RNA targets. This action helps maintain the efficiency and fidelity of mitochondrial protein production which is essential for normal cellular function.
Pathways
PDE12 plays a significant role in regulating the mitochondrial respiratory chain impacting cellular energy metabolism. Its function aligns closely with pathways involved in oxidative phosphorylation where it ensures the correct processing of mitochondrial-encoded factors necessary for electron transport chain function. PDE12 operates in conjunction with other proteins like TRNT1 and ELAC2 which also participate in mitochondrial RNA processing and contribute to the integrity of mitochondrial gene expression.
Specifications
Form
Liquid
Additional notes
Purity determined by densitometry. Affinity purified.
General info
Function
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed : 26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed : 21666256, PubMed : 26055709, PubMed : 30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed : 26055709).
Sequence similarities
Belongs to the CCR4/nocturin family.
Subcellular localisation
Mitochondrion matrix
Target data
Complementary Products
Product promise
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