Recombinant human PDE3A protein (His tag N-Terminus + GST tag N-Terminus)
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Recombinant human PDE3A protein (His tag N-Terminus + GST tag N-Terminus) is a Human Fragment protein, in the 669 to 1141 aa range, expressed in Baculovirus infected Sf9 cells, with >82%, suitable for SDS-PAGE, FuncS.
View Alternative Names
Cyclic GMP-inhibited phosphodiesterase A, cGMP-inhibited cAMP phosphodiesterase, CGI-PDE A, cGI-PDE, PDE3A
- FuncS
Supplier Data
Functional Studies - Recombinant human PDE3A protein (His tag N-Terminus + GST tag N-Terminus) (AB198445)
Example of specific activity of ab198445.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human PDE3A protein (His tag N-Terminus + GST tag N-Terminus) (AB198445)
10% SDS-PAGE with Coomassie staining : 5 μg ab198445.
Complementary Products
Primary Antibodies
AB315280
Anti-PDE3A antibody [EPR28228-6] - BSA and Azide free
Recombinant|RabMAb
![Western blot - Anti-PDE3A antibody [EPR28228-6] - BSA and Azide free (AB315280)](https://content.abcam.com/products/images/pde3a-antibody-epr28228-6-bsa-and-azide-free-ab315280--western-blot-img427398.jpg)
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Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Phosphodiesterase 3A plays an important role in cardiac and vascular functions. It forms part of a signaling complex responsible for regulating cardiovascular responses. PDE3A manages intracellular cAMP and cGMP concentrations impacting vascular smooth muscle relaxation and platelet aggregation. The modulation of these signaling molecules by PDE3A contributes to maintaining normal heart rhythms and influencing blood pressure.
Pathways
Phosphodiesterase 3A is central to the cAMP and cGMP signaling pathways. PDE3A activity connects to the cardiac contractility pathway where it works alongside proteins like protein kinase A (PKA) which depends on cAMP levels. In the vascular system PDE3A activity is interlinked with the nitric oxide (NO) pathway where it modulates the effects of cGMP-dependent protein kinase (PKG). Together they orchestrate vascular actions such as smooth muscle contraction and vasodilation.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed : 1315035, PubMed : 25961942, PubMed : 8155697, PubMed : 8695850). Also has activity toward cUMP (PubMed : 27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed : 31420216, PubMed : 34707099).
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
Target data
Product promise
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