Recombinant human PDE4B3 protein (Active) (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDE4B3 also known as phosphodiesterase 4B3 is an isoform of the PDE4B enzyme. This enzyme has a mass of approximately 80 kDa. PDE4B3 regulates intracellular levels of cyclic AMP (cAMP) by hydrolyzing cAMP to 5’-AMP therefore controlling signaling pathways that depend on this second messenger. PDE4B3 expression occurs mainly in cells of the immune system especially in leukocytes as well as in the brain.

Biological function summary

The activity of PDE4B3 modulates immune responses and central nervous system functions by determining the concentration of cAMP. PDE4B3 is part of a larger family of phosphodiesterases that degrade cAMP. This regulation of cAMP influences important cellular processes such as gene expression and inflammatory responses highlighting its role within complex signaling networks that maintain cellular homeostasis.

Pathways

PDE4B3 plays a critical role in signaling pathways like the cAMP-dependent signaling pathway. It directly interacts with proteins involved in these pathways such as protein kinase A (PKA) to control downstream effects related to inflammation and neurotransmission. PDE4B3's degradation of cAMP serves as a negative feedback mechanism in these pathways. It shares functional similarities with other PDE4 family members but its distinct expression pattern provides its unique contributions to these pathways.

PDE4B3 has been implicated in several conditions including depression and chronic obstructive pulmonary disease (COPD). Studies link altered PDE4B3 activity to dysregulation of cAMP metabolism which affects inflammatory processes and neurotransmitter release associated with these diseases. Additionally its interaction with proteins such as PKA highlights potential therapeutic targets for modulating PDE4B3 activity in these conditions.