JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB275909

Recombinant Human PDE6D protein (Tagged)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human PDE6D protein (Tagged) is a Human Full Length protein, in the 1 to 150 aa range, expressed in Wheat germ, suitable for SDS-PAGE.

View Alternative Names

PDED, PDE6D, GMP-PDE delta, Protein p17

1 Images
SDS-PAGE - Recombinant Human PDE6D protein (Tagged) (AB275909)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PDE6D protein (Tagged) (AB275909)

12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O43924

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV","proteinLength":"Full Length","predictedMolecularWeight":"42.24 kDa","actualMolecularWeight":null,"aminoAcidEnd":150,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O43924","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PDE6D protein also known as Phosphodiesterase Delta or PDE6 delta serves a mechanical function as a prenyl-binding protein. It facilitates the release of prenylated proteins from cellular membranes allowing their proper trafficking within the cell. PDE6D has a molecular mass of approximately 17 kDa and is a part of the larger phosphodiesterase family. Expression of this target occurs mainly in retinal photoreceptor cells but is also found in several other tissues such as the brain and kidneys.
Biological function summary

PDE6D plays a role in the proper localization and function of various prenylated proteins contributing to retinal function. It is important for ciliary targeting allowing proteins like the small GTPase Ras and the retinitis pigmentosa protein RPGR to localize correctly. PDE6D itself does not form part of a larger complex but facilitates the interaction between proteins and other cell components ensuring that cellular processes proceed as needed.

Pathways

PDE6D functions as an important player in small GTPase-mediated signal transduction. This protein interacts with the Ras superfamily of small GTPases important for intracellular signaling pathways. It plays a role in processes such as cell growth differentiation and apoptosis. The proper functioning of PDE6D ensures that prenylated proteins like Ras which are also implicated in these pathways are effectively transported to their destinations within the cell.

PDE6D has been linked to retinitis pigmentosa a degenerative eye disease leading to retinal dysfunction. Mutations in the PDE6D gene disrupt the proper trafficking of prenylated proteins including RPGR which is essential for photoreceptor cell survival and function. Additionally PDE6D may also play a role in Joubert syndrome where it affects the localization of proteins necessary for proper ciliary function contributing to the disorders observed in this syndrome.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Promotes the release of prenylated target proteins from cellular membranes (PubMed : 9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed : 22002721, PubMed : 23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed : 24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).

Sequence similarities

Belongs to the PDE6D/unc-119 family.

Subcellular localisation

Cytoskeleton

style
left-column

Product protocols

style
left-column

Target data

Promotes the release of prenylated target proteins from cellular membranes (PubMed : 9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed : 22002721, PubMed : 23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed : 24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).
See full target information PDE6D
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB96825

Anti-PDE6D antibody

Western blot - Anti-PDE6D antibody (AB96825)

  • 0
  • 0
Proteins & Peptides

AB134592

Recombinant Human SPSB2 protein

SDS-PAGE - Recombinant Human SPSB2 protein (AB134592)

  • 0
  • 0
Proteins & Peptides

AB99389

Recombinant Human DIRAS1 protein

SDS-PAGE - Recombinant Human DIRAS1 protein (AB99389)

  • 0
  • 0
Proteins & Peptides

AB101821

Recombinant Human AUH protein

SDS-PAGE - Recombinant Human AUH protein (AB101821)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com