Recombinant Human PDZD11 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDZD11 also known as PDZ domain containing 11 is a small protein with a mass of approximately 16 kDa. It contains a PDZ domain which allows for interaction with other proteins. This protein expresses in various tissues with notable levels in the brain heart and skeletal muscle. Mechanically PDZD11 interacts with other PDZ domain-containing proteins aiding in scaffolding functions that are important for many cellular processes.

Biological function summary

PDZD11 plays a role in organizing protein complexes at the plasma membrane which are important for signaling pathways. It is part of the protein complex involved in cellular signaling and communication. The scaffolding ability can influence interactions and maintenance of cellular function by anchoring essential signaling molecules which includes proteins involved in maintaining synaptic structures in neurons.

Pathways

Studies show the involvement of PDZD11 in the regulation of the MAPK signaling pathway and the organization of cytoskeletal components. It plays a part by interacting with other proteins in the pathway such as kinases and phosphatases facilitating proper signal transduction and cellular response to stimuli. Within the MAPK signaling pathway it contributes by helping regulate cellular activities like gene expression and cell division which are essential for cell growth and differentiation.

PDZD11 has shown connections to neurological disorders and muscle pathologies. For instance variants affecting PDZD11 function might contribute to cognitive disorders due to its role in synaptic maintenance and also muscle diseases because of its expression in skeletal muscle tissues. The interactions with proteins involved in these conditions may reveal therapeutic targets providing new directions for treatments focusing on overcoming or compensating dysfunctional protein interactions.