Recombinant Human PEA15 protein (Tag Free)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PEA15 also known as phosphoprotein enriched in astrocytes 15 or PED is a multifunctional protein weighing around 15 kDa. Mechanically PEA15 acts as a death effector domain (DED)-containing protein that modulates diverse cellular processes by binding to and inhibiting other DED-containing proteins. This protein shows wide expression notably in the central nervous system including the brain where it exerts critical roles in signaling networks.

Biological function summary

PEA15 plays pivotal roles in promoting cellular survival and regulating apoptosis within various cell types. It operates by modulating pathways like apoptosis and cell proliferation often forming complexes with other DED-containing proteins such as FADD and caspase-8. By interacting with these proteins PEA15 can maintain cellular stability and manage stress responses illustrating its significant contribution to cellular homeostasis.

Pathways

PEA15 is integral in mediating the extracellular signal-regulated kinase (ERK) and MAP kinase pathways. As PEA15 binds to ERK1/2 it retains these kinases in the cytoplasm impeding their translocation to the nucleus and therefore affecting the transcription of target genes. Furthermore its interactions with Ras-related proteins indicate its involvement in the regulation of cell growth and differentiation showing its broad influence on cellular signaling cascades.

PEA15 correlates with neurological conditions including Alzheimer's disease and gliomas. In Alzheimer's disease PEA15 modulates neuroinflammation and amyloid precursor protein processing collaborating with proteins such as tau and amyloid-beta. In gliomas alterations in PEA15 expression influence tumor progression and treatment susceptibility highlighting important intersections with oncogenic factors like EGFR and PTEN. These associations spotlight PEA15 as a potential therapeutic target in both neurodegenerative and cancerous disorders.