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AB161530

Recombinant Human PEG10/EDR protein (GST tag N-Terminus)

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Recombinant Human PEG10/EDR protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 325 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

EDR, KIAA1051e, MAR2, MART2, MEF3L1, RGAG3, PEG10, Retrotransposon-derived protein PEG10, Embryonal carcinoma differentiation-regulated protein, Mammalian retrotransposon-derived protein 2, Myelin expression factor 3-like protein 1, Paternally expressed gene 10 protein, Retrotransposon gag domain-containing protein 3, Retrotransposon-derived gag-like polyprotein, Ty3/Gypsy-like protein, MEF3-like protein 1

1 Images
SDS-PAGE - Recombinant Human PEG10/EDR protein (GST tag N-Terminus) (AB161530)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PEG10/EDR protein (GST tag N-Terminus) (AB161530)

ab161530 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q86TG7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Primary Antibodies

AB215035

Anti-PEG10/EDR antibody [EPR20051]

RabMAb|Recombinant|KO Validated|20ul selling size|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-PEG10/EDR antibody [EPR20051] (AB215035)

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Recombinant Human VCX-A protein (GST tag N-Terminus)

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Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as PEG10.
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Sequence info

[{"sequence":"MTERRRDELSEEINNLREKVMKQSEENNNLQSQVQKLTEENTTLREQVEPTPEDEDDDIELRGAAAAAAPPPPIEEECPEDLPEKFDGNPDMLAPFMAQCQIFMEKSTRDFSVDRVRVCFVTSMMTGRAARWASAKLERSHYLMHNYPAFMMEMKHVFEDPQRREVAKRKIRRLRQGMGSVIDYSNAFQMIAQDLDWNEPALIDQYHEGLSDHIQEELSHLEVAKSLSALIGQCIHIERRLARAAAARKPRSPPRALVLPHIASHHQVDPTEPVGGARMRLTQEEKERRRKLNLCLYCGTGGHYADNCPAKASKSSPAGNSPAPL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":325,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86TG7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PEG10 also known as EDR2 is a paternally expressed imprinted gene that encodes the PEG10 protein. The PEG10 protein has a molecular mass of approximately 150 kDa. It shows expression most notably in the placenta during development but also in other tissues like the liver and brain. The protein contains two open reading frames that produce different products via a frameshift mechanism similar to retroviral proteins.
Biological function summary

The PEG10 protein plays multiple roles especially in cell proliferation apoptosis inhibition and promoting cell survival. It can be part of larger protein complexes that modulate cellular responses to stress and developmental cues. The protein's multifaceted activities are important during embryogenesis where it supports trophoblast development and placental formation.

Pathways

PEG10 interacts with signaling cascades such as the TGF-beta signaling pathway and is involved in cell cycle regulation. PEG10 works alongside proteins like paternally expressed genes that connect with TGF-beta pathways influencing cellular differentiation and growth. Its integration in these pathways highlights its role in managing cellular environments and responses to cellular stress signals.

PEG10 expression over-activation has associations with cancer especially hepatocellular carcinoma and pancreatic cancer. In these contexts PEG10 interacts with proteins like H3L3 contributing to oncogenic pathways that drive tumor cell proliferation and survival. Elevated levels of PEG10 can serve as potential biomarkers for certain cancers suggesting their role in disease progression and possible therapeutic targeting.
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Specifications

Form

Liquid

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General info

Function

Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed : 34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed : 34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed : 34413232). Involved in placenta formation : required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression : promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed : 12810624, PubMed : 16423995, PubMed : 26235627, PubMed : 28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed : 15611116, PubMed : 26235627, PubMed : 30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).

Post-translational modifications

Isoform 1. Undergoes proteolytic cleavage.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed : 34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed : 34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed : 34413232). Involved in placenta formation : required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression : promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed : 12810624, PubMed : 16423995, PubMed : 26235627, PubMed : 28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed : 15611116, PubMed : 26235627, PubMed : 30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).
See full target information PEG10
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