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AB163508

Recombinant Human Pellino 2 protein (GST tag N-Terminus)

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Recombinant Human Pellino 2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 420 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

E3 ubiquitin-protein ligase pellino homolog 2, Pellino-2, RING-type E3 ubiquitin transferase pellino homolog 2, PELI2

1 Images
SDS-PAGE - Recombinant Human Pellino 2 protein (GST tag N-Terminus) (AB163508)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Pellino 2 protein (GST tag N-Terminus) (AB163508)

ab163508 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9HAT8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHNWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPID","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":420,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9HAT8","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Pellino 2 also known as PELI2 is an E3 ubiquitin ligase. It is about 45 kDa in mass and exists in the cytoplasm. This protein plays an important role in the regulation of the innate immune response. It is highly expressed in immune cells like monocytes and macrophages as well as in tissues such as the spleen and lymph nodes. As an adaptor molecule Pellino 2 modifies proteins by attaching ubiquitin which tags them for degradation or alters their activity.
Biological function summary

Pellino 2 engages in downstream signaling of immune receptors. It has a critical role in the activation of transcription factors contributing to the production of pro-inflammatory cytokines. Acting in a complex with other components like TRAF proteins it regulates the nuclear factor kappa B (NF-kB) signaling pathway. Through this regulation Pellino 2 influences inflammatory responses and aids in controlling the duration and intensity of inflammation.

Pathways

Pellino 2 integrates into the Toll-like receptor (TLR) and interleukin-1 (IL-1) signaling pathways. These pathways are fundamental for initiating the innate immune response upon detecting pathogens. Pellino 2 interacts with proteins like IRAK4 and MyD88 in these pathways facilitating the activation and amplification of signal cascades that lead to NF-kB and mitogen-activated protein kinase (MAPK) activation which further influence gene expression and immune responses.

Pellino 2 links with inflammatory conditions such as rheumatoid arthritis and cardiovascular disease. Abnormal regulation or expression of Pellino 2 may enhance inflammatory signaling contributing to the pathogenesis of these disorders. The protein's interaction with NF-kB an important player in many inflammatory diseases makes it an important factor in understanding and potentially modulating these pathological processes.
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Specifications

Form

Liquid

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General info

Function

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

Sequence similarities

Belongs to the pellino family.

Post-translational modifications

Phosphorylated by IRAK1 and IRAK4 enhancing its E3 ligase activity.

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Product protocols

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Target data

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
See full target information PELI2
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