JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB196416

Recombinant Human Peregrin/BRPF1 protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(1 Publication)

Recombinant Human Peregrin/BRPF1 protein (His tag N-Terminus) is a Human Fragment protein, in the 628 to 746 aa range, expressed in Escherichia coli, with >69%, suitable for SDS-PAGE.

View Alternative Names

BR140, BRPF1, Peregrin, Bromodomain and PHD finger-containing protein 1, Protein Br140

1 Images
SDS-PAGE - Recombinant Human Peregrin/BRPF1 protein (His tag N-Terminus) (AB196416)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Peregrin/BRPF1 protein (His tag N-Terminus) (AB196416)

4-20% SDS-PAGE analysis of 3 μg ab196416 with Coomassie staining.

Key facts

Purity

>69% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P55201

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

style
left-column

Complementary Products

Primary Antibodies

AB259840

Anti-Peregrin/BRPF1 antibody [EPR24069-57]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Peregrin/BRPF1 antibody [EPR24069-57] (AB259840)

  • 0
  • 0
Proteins & Peptides

AB313361

Recombinant Human WFDC2 Protein (His tag)

Mass Spectrometry - Recombinant Human WFDC2 Protein (His tag) (AB313361)

  • 0
  • 0
Proteins & Peptides

AB217407

Recombinant human Vitronectin/S-Protein (Animal Free)

  • 0
  • 0
Proteins & Peptides

AB318256

Recombinant Clostridioides difficile Toxin B/TcdB Protein (His-tag)

Mass Spectrometry - Recombinant Clostridioides difficile Toxin B/TcdB Protein (His-tag) (AB318256)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

Product details

This product was previously labelled as Peregrin
style
left-column

Sequence info

[{"sequence":"MHHHHHHMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVTELDEVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVLRQARRQAEKMG","proteinLength":"Fragment","predictedMolecularWeight":"15.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":746,"aminoAcidStart":628,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P55201","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Peregrin/BRPF1 also known as Peregrins is a protein with a molecular mass around 130 kDa. It functions primarily as a component of the MOZ/MORF histone acetyltransferase (HAT) complex. Peregrin/BRPF1 plays a mechanical role in the regulation of gene expression by altering chromatin structure through histone modification. It is expressed in various tissues with higher expression in the brain and testis indicating its importance in neurological and reproductive functions.
Biological function summary

Peregrin/BRPF1 is a part of the MOZ/MORF complex which is important for acetylating histone H3 at lysine 23 influencing transcriptional activation. This action aids in transcription regulation and chromatin remodeling facilitating access of transcription factors to DNA. By participating in these processes Peregrin/BRPF1 helps maintain proper gene expression patterns essential for normal cell function and development.

Pathways

BRPF1 has roles in processes like the cell cycle and embryonic development pathways because its histone acetylation influences gene expression. It interacts with other acetyltransferases such as EP300 and CREBBP which play key roles in transcription regulation and chromatin remodeling within these pathways. These interactions highlight BRPF1's critical involvement in coordinating cellular events and developmental processes.

Dysregulation of BRPF1 is associated with neurological disorders such as intellectual disability and specific cancers due to its role in chromatin remodeling and gene expression. In the context of intellectual disability it interacts with other proteins involved in chromatin structure like NSD1 and KDM6A. These connections illustrate the significant impact of Peregrin/BRPF1's regulation and its influence on health when its function becomes impaired.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed : 16387653, PubMed : 24065767, PubMed : 27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed : 24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed : 27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed : 18794358).

Post-translational modifications

Acetylated by KAT6A.

Subcellular localisation

Nucleus

style
left-column

Product protocols

style
left-column

Target data

Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed : 16387653, PubMed : 24065767, PubMed : 27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed : 24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed : 27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed : 18794358).
See full target information BRPF1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

ChemMedChem 19:e202300590 PubMed38372199

2024

Accelerating BRPF1b hit identification with BioPhysical and Active Learning Screening (BioPALS).

Applications

Unspecified application

Species

Unspecified reactive species

Sandeep Pal,Zandile Nare,Vincenzo A Rao,Brian O Smith,Ian Morrison,Edward A Fitzgerald,Andrew Scott,Matilda J Bingham,Thomas Pesnot
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com