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Recombinant Human Perilipin-2 protein (denatured) is a Human Full Length protein, in the 1 to 437 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant Human Perilipin-2 protein (denatured) (AB181932), expandable thumbnail

Publications

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

T7 tag N-Terminus

Applications

SDS-PAGE

Biologically active

No

Amino acid sequence

< M A S M T G G Q Q M G R G S > M A S V A V D P Q P S V V T R V V N L P L V S S T Y D L M S S A Y L S T K D Q Y P Y L K S V C E M A E N G V K T I T S V A M T S A L P I I Q K L E P Q I A V A N T Y A C K G L D R I E E R L P I L N Q P S T Q I V A N A K G A V T G A K D A V T T T V T G A K D S V A S T I T G V M D K T K G A V T G S V E K T K S V V S G S I N T V L G S R M M Q L V S S G V E N A L T K S E L L V E Q Y L P L T E E E L E K E A K K V E G F D L V Q K P S Y Y V R L G S L S T K L H S R A Y Q Q A L S R V K E A K Q K S Q Q T I S Q L H S T V H L I E F A R K N V Y S A N Q K I Q D A Q D K L Y L S W V E W K R S I G Y D D T D E S H C A E H I E S R T L A I A R N L T Q Q L Q T T C H T L L S N I Q G V P Q N I Q D Q A K H M G V M A G D I Y S V F R N A A S F K E V S D S L L T S S K G Q L Q K M K E S L D D V M D Y L V N N T P L N W L V G P F Y P Q L T E S Q N A Q D Q G A E M D K S S Q E T Q R S E H K T H

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.

Alternative names

Recommended products

Recombinant Human Perilipin-2 protein (denatured) is a Human Full Length protein, in the 1 to 437 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE

Accession
Q99541-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

Sequence info

Amino acid sequence

< M A S M T G G Q Q M G R G S > M A S V A V D P Q P S V V T R V V N L P L V S S T Y D L M S S A Y L S T K D Q Y P Y L K S V C E M A E N G V K T I T S V A M T S A L P I I Q K L E P Q I A V A N T Y A C K G L D R I E E R L P I L N Q P S T Q I V A N A K G A V T G A K D A V T T T V T G A K D S V A S T I T G V M D K T K G A V T G S V E K T K S V V S G S I N T V L G S R M M Q L V S S G V E N A L T K S E L L V E Q Y L P L T E E E L E K E A K K V E G F D L V Q K P S Y Y V R L G S L S T K L H S R A Y Q Q A L S R V K E A K Q K S Q Q T I S Q L H S T V H L I E F A R K N V Y S A N Q K I Q D A Q D K L Y L S W V E W K R S I G Y D D T D E S H C A E H I E S R T L A I A R N L T Q Q L Q T T C H T L L S N I Q G V P Q N I Q D Q A K H M G V M A G D I Y S V F R N A A S F K E V S D S L L T S S K G Q L Q K M K E S L D D V M D Y L V N N T P L N W L V G P F Y P Q L T E S Q N A Q D Q G A E M D K S S Q E T Q R S E H K T H

Accession

Q99541

Protein length

Full Length

Predicted molecular weight

49.3 kDa

Amino acids

1 to 437

Nature

Recombinant

Tags

T7 tag N-Terminus

Specifications

Form

Liquid

General info

Function

Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.

Sequence similarities

Belongs to the perilipin family.

Post-translational modifications

Acylated; primarily with C14, C16 and C18 fatty acids.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The protein Perilipin-2 also known as PLIN2 ADFP or adipophilin has an approximate molecular weight of 48 kDa. It is primarily expressed in tissues involved in lipid metabolism like adipose tissue liver and muscle. The main role of Perilipin-2 is to coat lipid droplets in cells thereby regulating lipid storage and breakdown. This protein serves as a critical component of the lipid droplet surface providing structure and protecting the lipid core from excessive unregulated lipolysis.

Biological function summary

Perilipin-2 is a member of the PAT family proteins involved in lipid droplet formation and maintenance. It does not typically form part of larger complexes but it plays a significant role in cellular energy regulation by controlling lipid reserves. This regulation ensures an efficient balance between energy storage and mobilization. The presence and levels of Perilipin-2 can influence how cells respond to nutrients particularly during periods of energy surplus or fasting.

Pathways

Perilipin-2 is heavily involved in the regulation of lipid metabolic pathways and the storage-related signaling cascades. It interacts with key metabolic proteins including hormone-sensitive lipase (HSL) to modulate lipolysis. By doing so Perilipin-2 influences processes like fatty acid mobilization and glycerol release integrating perfectly into the cellular energy balance system. The protein is also related to perilipin another member of the lipid droplet-associated proteins emphasizing its participation in lipid metabolism.

Associated diseases and disorders

Altered expression of Perilipin-2 can have implications in obesity and fatty liver disease. The protein is involved in the accumulation of lipid droplets which is a common feature in these conditions. Obesity and associated disorders often show elevated levels of Perilipin-2 which mirrors increased lipid storage capacity. The protein’s interplay with adipose tissue composition highlights its connection to obesity-related factors including other lipid droplet-associated proteins like adipose triglyceride lipase (ATGL) which influence the progression of metabolic diseases.

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1 product image

  • SDS-PAGE - Recombinant Human Perilipin-2 protein (denatured) (ab181932), expandable thumbnail

    SDS-PAGE - Recombinant Human Perilipin-2 protein (denatured) (ab181932)




    3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.


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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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