Recombinant human Peroxiredoxin 6 protein

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Peroxiredoxin 6 also known as Prdx6 or peroxiredoxin-6 is a unique member of the peroxiredoxin family. It distinguishes itself by possessing both peroxidase and phospholipase A2 activities. This protein weighs approximately 25 kDa and is ubiquitously expressed in various tissues showing a high concentration in the lung. The expression pattern suggests its importance across different physiological contexts.

Biological function summary

We can understand peroxiredoxin 6 as a versatile enzyme that reduces hydrogen peroxide and organic hydroperoxides. It does not form a complex like some other peroxiredoxins. Instead it acts independently in cellular protection against oxidative stress. This role is mainly due to its peroxidase activity which helps in maintaining cellular redox balance and mitigating oxidative damage.

Pathways

Multiple cellular processes incorporate the enzymatic functions of peroxiredoxin 6. It plays an important role in the antioxidant defense pathway by collaborating with glutathione peroxidase to detoxify hydrogen peroxide. Another major pathway that involves Prdx6 is the phospholipid metabolism where it participates in the repair of oxidatively damaged cell membranes. This protein interacts with cytoplasmic thioredoxin proteins forming a network for managing intracellular reactive oxygen species.

Associated diseases and disorders

Peroxiredoxin 6 has significant implications. Researchers have linked it to lung cancer where its expression levels correlate with disease progression possibly interacting with oncogenic proteins like NF-kB. In addition peroxiredoxin 6 is associated with neurodegenerative diseases such as Alzheimer’s disease. Its function in oxidative stress regulation might influence the aggregation of proteins like Tau which is a hallmark of Alzheimer's pathology.