Recombinant Human PEX11A protein (Fc Chimera)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PEX11A also known as Peroxin 11 Alpha plays an important role in peroxisomal biogenesis. It weighs approximately 28 kDa and resides in the peroxisomal membrane. PEX11A is notably expressed in tissues with high metabolic activity like the liver and kidney. This protein participates in the processes of peroxisome membrane elongation and division ensuring proper peroxisome proliferation.

Biological function summary

This protein assists in regulating peroxisome dynamics and homeostasis. PEX11A is often associated with the formation of peroxisomes where it recruits other proteins to the peroxisomal membrane. It does not operate alone and acts as a part of a multi-protein complex which may include other PEX proteins. This complex arrangement facilitates the expansion and duplication of peroxisomal membranes.

Pathways

This protein integrates into the fatty acid β-oxidation and plasmalogen biosynthesis pathways. PEX11A influences these pathways by controlling peroxisome abundance which is critical for lipid metabolism within the cell. Within these pathways PEX11A interacts indirectly with proteins such as PEX5 and PEX14 ensuring peroxisomal import of matrix proteins essential for metabolic activity.

PEX11A alterations connect to Zellweger spectrum disorders and other peroxisomal biogenesis diseases. Mutations in this protein can lead to abnormal peroxisome function impacting cellular lipid metabolism. These disorders often show links to PEX1 and PEX6 proteins which also participate in peroxisome assembly and maintenance. Understanding PEX11A's expression and functioning provides insights into potential therapeutic approaches for these conditions.