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AB167869

Recombinant Human PEX26 protein

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Recombinant Human PEX26 protein is a Human Fragment protein, in the 1 to 246 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Peroxisome assembly protein 26, Peroxin-26, PEX26

1 Images
SDS-PAGE - Recombinant Human PEX26 protein (AB167869)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PEX26 protein (AB167869)

15% SDS-PAGE analysis of 3µg ab167869.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q7Z412

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris-HCl buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMKSDSSTSAAPLRGLGGPLRSSEPVRAVPARAPAVDLLEEAADLLVVHLDFRAALETCERAWQSLANHAVAEEPAGTSLEVKCSLCVVGIQALAEMDRWQEVLSWVLQYYQVPEKLPPKVLELCILLYSKMQEPGAVLDVVGAWLQDPANQNLPEYGALAEFHVQRVLLPLGCLSEAEELVVGSAAFGEERRLDVLQAIHTARQQQKQEHSGSEEAQKPNLEGSVSHKFLSLPMLVRQLWDSAVSH","proteinLength":"Fragment","predictedMolecularWeight":"29.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":246,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q7Z412","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PEX26 also known as Peroxin 26 is a protein critical for peroxisomal function. It has a molecular mass of approximately 33 kDa. PEX26 is localized in the peroxisomal membrane and is mainly expressed in various tissues including liver kidney and brain. Its role is important in the peroxisome import machinery where it anchors the PEX1-PEX6 complex to the peroxisome membrane enabling the transport and maintenance of matrix proteins necessary for peroxisome function.
Biological function summary

The importance of PEX26 lies in its role as part of the peroxisome biogenesis complex. It anchors PEX1 and PEX6 which are essential components for ATPase activity important for peroxisome assembly and function. This tightly regulated process ensures that peroxisomes function correctly in metabolic pathways such as fatty acid β-oxidation and reactive oxygen species detoxification.

Pathways

PEX26 is instrumental in the peroxisomal matrix protein import pathway. This pathway includes the interaction between PEX1 and PEX6 where PEX26 is an anchor within the membrane structure. The pathway's proper function is essential to cellular lipid metabolism and detoxification processes linking it to proteins such as PEX5 that acts as a receptor for matrix proteins targeting peroxisomes.

Defects in PEX26 often associate with peroxisome biogenesis disorders such as Zellweger Spectrum Disorders (ZSD). These disorders result from improper peroxisome function due to mutations in the PEX26 gene leading to various metabolic dysfunctions. PEX26 mutations are especially significant in Zellweger syndrome a severe form of ZSD. The inability to correctly bind PEX1 and PEX6 leads to defective peroxisomal assembly critically impacting cellular health and leading to clinical manifestations associated with these disorders.
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Specifications

Form

Liquid

Additional notes

ab167869 was purified using conventional chromatography techniques.

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General info

Function

Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes (PubMed : 12717447, PubMed : 12851857, PubMed : 16257970, PubMed : 16763195, PubMed : 16854980, PubMed : 21362118). PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane (PubMed : 12717447, PubMed : 12851857, PubMed : 16257970, PubMed : 16763195, PubMed : 16854980, PubMed : 21362118).

Sequence similarities

Belongs to the peroxin-26 family.

Subcellular localisation

Peroxisome membrane

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Product protocols

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Target data

Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes (PubMed : 12717447, PubMed : 12851857, PubMed : 16257970, PubMed : 16763195, PubMed : 16854980, PubMed : 21362118). PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane (PubMed : 12717447, PubMed : 12851857, PubMed : 16257970, PubMed : 16763195, PubMed : 16854980, PubMed : 21362118).
See full target information PEX26
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