Recombinant Human PFDN4 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PFDN4 protein also known as Prefoldin Subunit 4 is part of a multi-subunit chaperone complex. The protein has a molecular mass of approximately 16 kDa and consists of several hydrophobic regions. Widely expressed in the cytoplasm PFDN4 interacts with actin and tubulin through its role in the prefoldin complex. It aids in the proper folding of these cytoskeletal proteins supporting overall cellular functions.

Biological function summary

In cellular processes PFDN4 plays an important role as a component of the prefoldin complex. This complex is a heterohexameric assembly that supports the folding and transport of nascent polypeptide chains. Such activity is important for maintaining the stability and functionality of cytoskeletal proteins. By influencing protein conformation PFDN4 contributes to the structural integrity of cells.

Pathways

In the protein biosynthesis context PFDN4 is involved in cytoskeleton organization and protein folding pathways. The prefoldin complex including PFDN4 facilitates the proper assembly and stabilization of tubulin which is significant for maintaining microtubule dynamics. Additionally PFDN4's interactions with chaperonin-containing TCP-1 (CCT) carry out essential roles in these pathways highlighting its contribution to cytoskeletal homeostasis.

Research links PFDN4 to conditions involving cytoskeletal defects such as certain neurodegenerative diseases and cancer. The malfunction of the prefoldin complex as seen in aberrant PFDN4 activity can disrupt cellular architecture and lead to disease progression. In particular PFDN4's relationship with proteins like tubulin and actin signifies that alterations in these interactions might contribute to oncogenesis and cancer metastasis.