Recombinant Human PFDN5 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Prefoldin Subunit 5 (PFDN5) also known as PFD5 or MKBP is a protein that forms part of the prefoldin complex. This protein which has a mass of around 15.7 kDa plays an important mechanical role in delivering nascent polypeptide chains to the chaperonin complex for proper folding. PFDN5 is expressed widely across various tissues with notable expression in the brain and testis. Its involvement in such fundamental processes suggests it supports maintaining cellular stability and homeostasis.

Biological function summary

PFDN5 contributes to the assembly and stabilization of cytoskeletal structures by participating in tubulin folding processes. It functions as a component of the prefoldin complex a hexameric molecular chaperone. Through its action PFDN5 assists in the folding and assembly of cytoskeletal proteins such as actin and tubulin ensuring proper cellular architecture and transport functions. The protein’s interaction within the complex highlights its support in cellular dynamics and structural maintenance.

Pathways

PFDN5 integrates into important cellular pathways related to protein folding and cytoskeletal assembly. It participates prominently in the tubulin folding pathway which is essential for microtubule formation. In this context PFDN5 interacts significantly with chaperonin-containing T-complex protein 1 (CCT) to facilitate the assembly of tubulin monomers into functional microtubules. These interactions highlight PFDN5’s role in maintaining cellular integrity and facilitating intracellular transport mechanisms.

PFDN5 presents associations with certain cancers particularly glioma. Altered expression or function of PFDN5 can disrupt normal cytoskeletal processes contributing to the irregular cell proliferation observed in gliomas. It has shown interactions with proteins like CCT2 in such pathological conditions. Furthermore PFDN5’s involvement in neurodegenerative processes links it to diseases like amyotrophic lateral sclerosis (ALS). In these contexts PFDN5 might influence disease progression through its impact on protein stability and cellular architecture.